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Impact Of Metformin On Peak Aerobic Capacity, Barry Braun, Pamela Eze, Brooke R. Stephens, Todd A. Hagobian, Carrie G. Sharoff, Stuart R. Chipkin, Benjamin Goldstein
Impact Of Metformin On Peak Aerobic Capacity, Barry Braun, Pamela Eze, Brooke R. Stephens, Todd A. Hagobian, Carrie G. Sharoff, Stuart R. Chipkin, Benjamin Goldstein
Stuart R. Chipkin
Individually, exercise and the drug metformin have been shown to prevent or delay type 2 diabetes. Metformin mildly inhibits complex I of the electron transport system and may impact aerobic capacity in people exercising while taking metformin. The purpose of the study was to evaluate the effects of metformin on maximal aerobic capacity in healthy individuals without mitochondrial dysfunction. Seventeen healthy, normal-weight men (n=11) and women (n=6) participated in a double-blind, placebo-controlled, cross-over design. Peak aerobic capacity was measured twice using a continuous, incrementally graded protocol; once after 7-9 d of metformin (final dose=2000 mg/d) and once with placebo, with …