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Role Of Transforming Growth Factor (Tgf) – Β Signaling In Craniofacial Development, Malignancies And Regeneration, Jingpeng Liu
Role Of Transforming Growth Factor (Tgf) – Β Signaling In Craniofacial Development, Malignancies And Regeneration, Jingpeng Liu
Theses & Dissertations
The transforming growth factor (TGF) – β signaling pathway regulates a diversity of fundamental cellular processes such as cell growth and proliferation, cell differentiation, migration, apoptosis and other biological functions, both during embryogenesis and in adult tissue homeostasis. TGF-β is known to play a critical role in palatal development as in TGF-β knockout murine models, TGF-β deficiency causes cleft palate, a common craniofacial deformity in humans due to the abnormality of growth, elevation or fusion of the two palatal shelves. In order to investigate the mechanisms of how TGF-β regulates palatogenesis, we generated TGF-β3 knockout (-/-) murine models, performed systematic …