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The Influence Of Estrogen And Glucocorticoid On Th2 Cell Survival And Transcriptional Activation Of Crth2, Jenna H. Fortunato
The Influence Of Estrogen And Glucocorticoid On Th2 Cell Survival And Transcriptional Activation Of Crth2, Jenna H. Fortunato
Electronic Thesis and Dissertation Repository
Women are more likely to have severe asthma than men. Recent data suggest this could be due to women having more circulating CD4+CRTh2+ T cells (Th2 cells). Glucocorticosteroids (GC)s are the main therapy for asthma as they inhibit cytokine production and eliminate inflammatory cells by apoptosis. The current study examined whether the female sex hormone estrogen influences the anti-inflammatory action of GC. Experiments show that ER⍺ agonist reduced GC-induced apoptosis of primary Th2 cells and enhanced GC-mediated transcriptional activation of the proximal CRTh2 promoter. Genetic variation within CRTh2 is associated with asthma and allergic phenotypes. Using constructs …
Effect Of Estrogen And Glucocorticoid Signaling On Th2 Cells – Implications For Severe Asthma, Meerah Vijeyakumaran
Effect Of Estrogen And Glucocorticoid Signaling On Th2 Cells – Implications For Severe Asthma, Meerah Vijeyakumaran
Electronic Thesis and Dissertation Repository
T helper (Th2) cells are increased in asthma and mediate allergic inflammation through production of type 2 cytokines (interleukin-4, -5 and -13). One pathway to activate Th2 cells is through chemoattractant-homologous receptor expressed on Th2 cells (CRTh2), a receptor for prostaglandin D2 (PGD2). Glucocorticoids (GCs) are the main treatment for allergic disease, due to their ability to suppress type 2 cytokine production and induce apoptosis. Incidence and severity of asthma is greater in women than men, which may be related to sex-specific efficacy of GCs. Recently, our laboratory found that severe asthmatic women had more circulating Th2 …