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Full-Text Articles in Life Sciences
Copy Number Variation In The Porcine Genome Detected From Whole-Genome Sequence, Rebecca Anderson
Copy Number Variation In The Porcine Genome Detected From Whole-Genome Sequence, Rebecca Anderson
Honors Theses
Copy number variations (CNVs) are large insertions, deletions, and duplications in the genome that vary between individuals in a species. These variations are known to impact a broad range of phenotypes from molecular-level traits to higher-order clinical phenotypes. CNVs have been linked to complex traits in humans such as autism, attention deficit hyperactivity disorder, nervous system disorders, and early-onset extreme obesity. In this study, whole-genome sequence was obtained from 72 founders of an intensely phenotyped experimental swine herd at the U.S. Meat Animal Research Center (USMARC) in Clay Center, Nebraska. This included 24 boars (12 Duroc and 12 Landrace) and …
The Impact Of Truncating Data On The Predictive Ability For Single-Step Genomic Best Linear Unbiased Prediction, Jeremy T. Howard, Thomas A. Rathje, Caitlyn E. Bruns, Danielle F. Wilson-Wells, Stephen D. Kachman, Matthew L. Spangler
The Impact Of Truncating Data On The Predictive Ability For Single-Step Genomic Best Linear Unbiased Prediction, Jeremy T. Howard, Thomas A. Rathje, Caitlyn E. Bruns, Danielle F. Wilson-Wells, Stephen D. Kachman, Matthew L. Spangler
Department of Animal Science: Faculty Publications
Simulated and swine industry data sets were utilized to assess the impact of removing older data on the predictive ability of selection candidate estimated breeding values (EBV) when using single-step genomic best linear unbiased prediction (ssGBLUP). Simulated data included thirty replicates designed to mimic the structure of swine data sets. For the simulated data, varying amounts of data were truncated based on the number of ancestral generations back from the selection candidates. The swine data sets consisted of phenotypic and genotypic records for three traits across two breeds on animals born from 2003 to 2017. Phenotypes and genotypes were iteratively …
Fecal Microbiota Transplantation Is Associated With Reduced Morbidity And Mortality In Porcine Circovirus Associated Disease, Megan C. Niederwerder, Laura A. Constance, Raymond R. R. Rowland, Waseem Abbas, Samodha C. Fernando, Megan L. Potter, Maureen A. Sheahan, Thomas E. Burkey, Richard A. Hesse, Ada G. Cino-Ozuna
Fecal Microbiota Transplantation Is Associated With Reduced Morbidity And Mortality In Porcine Circovirus Associated Disease, Megan C. Niederwerder, Laura A. Constance, Raymond R. R. Rowland, Waseem Abbas, Samodha C. Fernando, Megan L. Potter, Maureen A. Sheahan, Thomas E. Burkey, Richard A. Hesse, Ada G. Cino-Ozuna
Department of Animal Science: Faculty Publications
Porcine circovirus associated disease (PCVAD) is a term used to describe the multifactorial disease syndromes caused by porcine circovirus type 2 (PCV-2), which can be reproduced in an experimental setting through the co-infection of pigs with PCV-2 and porcine reproductive and respiratory syndrome virus (PRRSV). The resulting PCVAD-affected pigs represent a subpopulation within the co-infected group. In co-infection studies, the presence of increased microbiome diversity is linked to a reduction in clinical signs. In this study, fecal microbiota transplantation (FMT) was investigated as a means to prevent PCVAD in pigs co-infected with PRRSV and PCV-2d. The sources of the FMT …