Life Sciences Commons^™

Jewish Genetic Diseases: Knowledge Of Reproductive Risk And Cancer Predisposition Among Young Adults Of Ashkenazi Descent, Hayley Kathleen Granger

Theses and Dissertations

Founder mutations within the Ashkenazi Jewish (AJ) population are associated with significantly higher carrier rates for certain severe, life-limiting conditions collectively called Jewish Genetic Diseases (JGDs), and for pathogenic variants in the BRCA1 and BRCA2 (BRCA1/2) cancer susceptibility genes. Efforts to educate AJ individuals about the implications of these founder mutations and available testing have increased the past forty years; however, studies suggest AJ individuals are not well educated on the topic (Hardy et al., 2022; Kaback, 2001; Warsch et al., 2014). Studies evaluating the reason for this gap in knowledge of young AJ adults are lacking. This study aimed …