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Evaluating The Influence Of Environmental Factors On The Rate Of Extra-Pair Matings In Tropical And Temperate Populations Of The House Wren (Troglodytes Aedon), Kaitlin Claire Mckenney
Evaluating The Influence Of Environmental Factors On The Rate Of Extra-Pair Matings In Tropical And Temperate Populations Of The House Wren (Troglodytes Aedon), Kaitlin Claire Mckenney
Theses and Dissertations
Considerable variation exists in the rate of extra-pair matings (EPMs) in birds. Environmental variability likely influences EPM rates within species, but the effects of local environmental factors on EPM rates are largely unpredictable. To determine whether broad-scale environmental factors might be better predictors of EPM rates within species, we quantified levels of extra-pair paternity in the house wren (Troglodytes aedon) in four populations spanning a range of latitude, elevation, and primary productivity (measured by actual evapotranspiration rates). Our results indicated an intermediate and variable level of EPM among populations (6 -31% extra-pair young) that was not significantly affected by 3 …
A Synthetic Biology Approach To Engineering New Anticancer Agents, Shane Robert Wesener
A Synthetic Biology Approach To Engineering New Anticancer Agents, Shane Robert Wesener
Theses and Dissertations
Histone deacetylase (HDAC) inhibitors are becoming increasingly valuable therapeutic agents in treatment of several types of malignancies. FK228 is a depsipeptde anticancer compound produced by Chromobacterium violaceum no. 968 through a nonribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) hybrid assembly line. In the present study, reconstitution of the biosynthetic pathway responsible for the production of FK228 revealed cross-talk between modular PKS and fatty acid synthase. This pathway contains two PKS modules on the DepBC enzymes that lack a functional acyltransferase (AT) domain, and no apparent AT-encoding gene exists within the gene cluster or its vicinity. We reported through heterologous expression of …
Phylogeographic Inference Of Insular Mule Deer (Odocoileus Hemionus) Divergence In North America's Desert Southwest, Ona Alminas
Phylogeographic Inference Of Insular Mule Deer (Odocoileus Hemionus) Divergence In North America's Desert Southwest, Ona Alminas
Theses and Dissertations
Though mule deer (Odocoileus hemionus) persist in robust populations throughout most of their North American distribution, nearly 60% of their historic range in México has declined due to habitat loss and unregulated hunting. Two of the six subspecies inhabiting México's deserts and Baja California peninsula are of conservation concern, occurring on land bridge islands in the Pacific Ocean (O. h. cerrosensis on Cedros Island: threatened) and in the Sea of Cortés (O. h. sheldoni on Tiburón Island: endangered). Focusing on the desert southwest (n=449 deer), we obtained 1,611 bp of mtDNA sequence (control region: 583 bp; cytochrome b gene: 1,028 …
Prolonged Glucose Deprivation Sensitizes Snf1 To Negative Regulation By Pka To Delay Entry Into Quiescence, Leah Bernadette Doughty
Prolonged Glucose Deprivation Sensitizes Snf1 To Negative Regulation By Pka To Delay Entry Into Quiescence, Leah Bernadette Doughty
Theses and Dissertations
AMPK, the fuel gauge of the cell, and its upstream kinase, LKB1, have been implicated in cancer prevention and stress response associated with energy exhaustion. In the yeast Saccharomyces cerevisiae, Snf1 is the ortholog of mammalian AMPK. In S. cerevisiae, Snf1 is activated by phosphorylation of its T–loop at Thr210, primarily by its upstream kinase Sak1, in absence of the preferred carbon source, glucose, or during some other stress responses. Cyclic AMP–dependent protein kinase A, PKA, is involved in nutrient signaling largely antagonistically to Snf1. Using yeast strains of the Sigma 1278b genetic background, which have a high basal level …