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Novel Functions For Neuronal Rna Processing Bodies In The Control Of Axon Terminal Growth In Drosophila Melanogaster, Sarala Joshi Pradhan
Novel Functions For Neuronal Rna Processing Bodies In The Control Of Axon Terminal Growth In Drosophila Melanogaster, Sarala Joshi Pradhan
Electronic Theses and Dissertations
In this thesis we first characterized neuronal functions for HPat/Pat1, a core component of RNA processing bodies or "P bodies". We show that hpat mutants exhibit a strong synaptic hyperplasia at the developing and acutely stimulated Drosophila larval neuromuscular junctions (NMJs). The synaptic defects observed in hpat mutants are associated with rearrangement of the axonal microtubule cytoskeleton suggesting that HPat negatively regulates presynaptic microtubule-based growth during NMJ development. Interestingly, we also found that both pre-and postsynaptic HPat expression controlled rapid axon terminal growth in response to acute spaced synaptic stimulation. We also demonstrate that HPat interacts genetically with the catalytic …
Isolation And Characterization Of A Full Length Retrotransposon: Cr1, Cassandra Michelle Weason
Isolation And Characterization Of A Full Length Retrotransposon: Cr1, Cassandra Michelle Weason
Electronic Theses and Dissertations
Transposable elements (TE) have been found in all genomes and have clearly had a major impact on genomic evolution. The described research takes advantage of an abundant transposable element present in the genomes of Anseriformes, called Chicken Repeat 1 (CR1). Previous studies in Anseriformes suggest that CR1 is presently active in recent evolutionary time (St. John, 2004). A fully functional CR1 element itself is approximately 4.5kb long (Kajikawa, 1997), where almost all inserts are truncated at the 5' end. Because of this, it has been a challenge to isolate a full length, active element. In this study, two CR1 sequences …