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Glucose And Acute Exercise Influence Factors Secreted By Circulating Angiogenic Cells In Vitro, Sarah Witkowski, Gayatri Guhanarayan, Rachel Burgess
Glucose And Acute Exercise Influence Factors Secreted By Circulating Angiogenic Cells In Vitro, Sarah Witkowski, Gayatri Guhanarayan, Rachel Burgess
Exercise and Sport Studies: Faculty Publications
Circulating angiogenic cells (CAC) influence vascular repair through the secretion of proangiogenic factors and cytokines. While CAC are deficient in patients with diabetes and exercise has a beneficial effect on CACs, the impact of these factors on paracrine secretion from CAC is unknown. We aimed to determine whether the in vitro secretion of selected cytokines and nitric oxide (NO) from CAC is influenced by hyperglycemia and acute exercise. Colonyforming unit CAC (CFU-CAC) were cultured from young active men (n = 9, 24 ± 2 years) at rest and after exercise under normal (5 mmol/L) and elevated (15 mmol/L) glucose. Preliminary …