Life Sciences Commons^™

Mechanisms Of Carnitine-Mediated Modulation Of Aflatoxin B1-Dna Adduct Formation, Ayub Mohd Yatim

Doctoral Dissertations

The main purpose of this study was to investigate the possible mechanism(s) of L-carnitine-mediated modulation of AFB₁-DNA adducts formation. The first part of the study investigated the effect of increased doses of carnitine on AFB₁ binding to macromolecules, AFB₁ uptake, activity of glutathione S-transferase (GST), and total glutathione concentrations in freshly isolated hepatocytes. Carnitine dose was significantly correlated with the formation of AFB₁-DNA adduct ( r = -0.68;p = 0.0002 ), AFB₁-protein adduct (r = 0.58;p = 0.017), but not AFB₁-RNA adduct (r = 0.14;p = 0.604). …

The Factors Affecting The Transfer Of Training Based On The Opportunity To Perform Trained Tasks, David Arnold Blair

Doctoral Dissertations

The purpose of this study was to identify and define the factors that affect the transfer of newly learned skills to the job. One factor that has been shown to affect the transfer of training to the job is the extent to which the training participants are given the opportunity to perform trained tasks once they return to their jobs. The opportunity to perform was to consist of two dimensions: breadth and activity level.

Training participants from a government facility and their immediate supervisors (N = 74) responded to two different questionnaires which measured the three dimensions of the opportunity …