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Articles 1 - 8 of 8
Full-Text Articles in Life Sciences
Making And Keeping Your Cattle Herd Safe From Bovine Viral Diarrhea (Bvd), Kerry A. Rood, C Kim Chapman, Allen Young
Making And Keeping Your Cattle Herd Safe From Bovine Viral Diarrhea (Bvd), Kerry A. Rood, C Kim Chapman, Allen Young
All Current Publications
This publication provides steps for keeping cattle herds safe from Bovine Viral Diarrhea (BVD).
18th Biennial Cheese Industry Conference, Various Authors
18th Biennial Cheese Industry Conference, Various Authors
Cheese Industry Conference
No abstract provided.
2008 Annual Report, Various Authors
A New Mouse-Adapted Strain Of Sars-Cov As A Lethal Model Forevaluating Antiviral Agents In Vitro And In Vivo, C. W. Day, R. Baric, S. X. Cai, M. Frieman, Y. Kumaki, John D. Morrey, Donald F. Smee, Dale L. Barnard
A New Mouse-Adapted Strain Of Sars-Cov As A Lethal Model Forevaluating Antiviral Agents In Vitro And In Vivo, C. W. Day, R. Baric, S. X. Cai, M. Frieman, Y. Kumaki, John D. Morrey, Donald F. Smee, Dale L. Barnard
Animal, Dairy, and Veterinary Science Faculty Publications
Severe acute respiratory syndrome (SARS) is a highly lethal emerging disease caused by coronavirus SARS-CoV. New lethal animal models for SARS were needed to facilitate antiviral research. We adapted and characterized a new strain of SARS-CoV (strain v2163) that was highly lethal in 5–6 week old BALB/c mice. It had nine mutations affecting 10 amino acid residues. Strain v2163 increased IL-1α, IL-6, MIP-1α, MCP-1, and RANTES in mice, and high IL-6 expression correlated with mortality. The infection largely mimicked human disease, but lung pathology lacked hyaline membrane formation. In vitro efficacy against v2163 was shown with known inhihibitors of SARSCoV …
A Recombinant,Infectious Human Parainfluenza Virus Type 3 Expressing The Enhanced Green Fluorescentprotein For Use In High-Throughput Antiviral Assays, J. P. Roth, J. K. Li, Donald F. Smee, John D. Morrey, Dale L. Barnard
A Recombinant,Infectious Human Parainfluenza Virus Type 3 Expressing The Enhanced Green Fluorescentprotein For Use In High-Throughput Antiviral Assays, J. P. Roth, J. K. Li, Donald F. Smee, John D. Morrey, Dale L. Barnard
Animal, Dairy, and Veterinary Science Faculty Publications
The ability to rescue an infectious, recombinant, negative-stranded, RNA virus from a cDNA clone, has led to new opportunities for measuring viral replication from a viral expressed reporter gene. In this study, the enhanced green fluorescent protein (EGFP) gene was inserted into the human parainfluenza virus type 3 (HPIV-3) antigenome and a recombinant, infectious virus was rescued. Maximum EGFP expression levels, measured by fluorescence, were seen at day 3. Comparison of a three-day, viral expressed EGFP fluorescence assay to a seven-day, neutral red assay, based on complete cell destruction in virus infected MA-104 cells, yielded Z′-factor values of 0.83 and …
Animal Models For The Study Of Influenza Pathogenesis And Therapy, Dale L. Barnard
Animal Models For The Study Of Influenza Pathogenesis And Therapy, Dale L. Barnard
Animal, Dairy, and Veterinary Science Faculty Publications
Influenza A viruses causes a variety of illnesses in humans. The most common infection, seasonal influenza, is usually a mild, self-limited febrile syndrome, but it can be more severe in infants, the elderly, and immunodeficient persons, in whom it can progress to severe viral pneumonitis or be complicated by bacterial superinfection, leading to pneumonia and sepsis. Seasonal influenza also occasionally results in neurologic complications. Rarely, viruses that have spread from wild birds to domestic poultry can infect humans; such “avian influenza” can range in severity from mild conjunctivitis through the rapidly lethal disease seen in persons infected with the H5N1 …
Inducible Bronchus-Associated Lymphoid Tissue Elicited By A Protein Cage Nanoparticle Enhances Protectionin Mice Against Diverse Respiratory Viruses, J. A. Wiley, L. E. Richert, S. D. Swain, A. Harmsen, Dale L. Barnard, T. D. Randall, M. Jutila, T. Douglas, C. Broomell, M. Young, A. Harmsen
Inducible Bronchus-Associated Lymphoid Tissue Elicited By A Protein Cage Nanoparticle Enhances Protectionin Mice Against Diverse Respiratory Viruses, J. A. Wiley, L. E. Richert, S. D. Swain, A. Harmsen, Dale L. Barnard, T. D. Randall, M. Jutila, T. Douglas, C. Broomell, M. Young, A. Harmsen
Animal, Dairy, and Veterinary Science Faculty Publications
Destruction of the architectural and subsequently the functional integrity of the lung following pulmonary viral infections is attributable to both the extent of pathogen replication and to the host-generated inflammation associated with the recruitment of immune responses. The presence of antigenically disparate pulmonary viruses and the emergence of novel viruses assures the recurrence of lung damage with infection and resolution of each primary viral infection. Thus, there is a need to develop safe broad spectrum immunoprophylactic strategies capable of enhancing protective immune responses in the lung but which limits immune-mediated lung damage. The immunoprophylactic strategy described here utilizes a protein …
Transcriptional Reprogramming Of Gene Expression In Bovine Somatic Cell Chromatin Transfer Embryos, N. Rodriguez-Osorio, Zhongde Wang, G. P. Page, J. M. Robl, E. Memili
Transcriptional Reprogramming Of Gene Expression In Bovine Somatic Cell Chromatin Transfer Embryos, N. Rodriguez-Osorio, Zhongde Wang, G. P. Page, J. M. Robl, E. Memili
Animal, Dairy, and Veterinary Science Faculty Publications
Background Successful reprogramming of a somatic genome to produce a healthy clone by somatic cells nuclear transfer (SCNT) is a rare event and the mechanisms involved in this process are poorly defined. When serial or successive rounds of cloning are performed, blastocyst and full term development rates decline even further with the increasing rounds of cloning. Identifying the "cumulative errors" could reveal the epigenetic reprogramming blocks in animal cloning. Results Bovine clones from up to four generations of successive cloning were produced by chromatin transfer (CT). Using Affymetrix bovine microarrays we determined that the transcriptomes of blastocysts derived from the …