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Interrelationships Among Magnesium Deficiency, Ketogenic Diet, And Fasting On Seizure Susceptibility, Hamdia Mohammed Shahwan Ai-Hamdani
Interrelationships Among Magnesium Deficiency, Ketogenic Diet, And Fasting On Seizure Susceptibility, Hamdia Mohammed Shahwan Ai-Hamdani
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Fasting and ketogenic diet prevent seizures in epileptic children, magnesium-deficient rats and other animal models of seizure disorders. This effect has been attributed to increased levels of circulating ketone bodies. The purpose of this study was to determine the role of serum ketone bodies, measured as beta-hydroxybutyrate (BHB), in preventing audiogenically-induced seizures in weanling rats fed a magnesium-deficient diet for 17 days.
The effect on seizure susceptibility was investigated by feeding a magnesium-deficient diet to weanling rats for 17 days. Fasting and ketogenic diet (dietary medium chain triglycerides, MCT) markedly decreased seizure incidence that was associated with increased serum BHB …