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Lessons From Sicilian Centenarians For Anti-Ageing Medicine. The Oxi-Inflammatory Status, Calogero Caruso, Giulia Accardi, Anna Aiello, Anna Calabrò, Mattia Emanuela Ligotti, Giuseppina Candore

Translational Medicine @ UniSa

Population ageing is a great achievement of humanity, but it also represents a challenge that the Western world is currently facing, as ageing is associated with increased susceptibility to age-related inflammatory diseases. Therefore, it is necessary to fully understand the mechanisms of healthy ageing to prevent the harmful aspects of ageing. The study of long living ndividuals (LLIs) is a great model for trying to achieve this goal. Accordingly, the oxy-inflammatory status of Sicilian LLIs was reviewed in the present paper. Based on the reported data, anti-inflammatory and anti-oxidative stress strategies have been discussed, useful for delaying or avoiding the …

Globularia Alypum L. Modulates Inflammatory Markers In The Human Colon And Shows A Potential Antioxidant Role In Myeloid Leukemic Cells, Najla Hajji, Elodie Hudik, Paola Iovino, Nacim Zouari, Hichem Sebai, Oliver Nusse, Carolina Ciacci

Translational Medicine @ UniSa

Globularia alypum (GA), a plant of the Globulariacea family, has long been used as a traditional cure for inflammatory and metabolic illnesses.In addition to various in vitro model studies, the current work focuses on GA'santioxidant and anti-inflammatory properties in human colon biopsies.

Liquid Chromatography-Electrospray Ionization Mass Spectrometry identified the phenol components in GA aqueous extract (GAAE).The antioxidant ability of GAAE was tested in vitro utilizing chemiluminescence and flow cytometry using fluorescent yeastsn conjunction with PLB-985-human myeloid leukemia cells. Experiments on human colon biopsies after a biopsy challenge with Escherichia coli-lipopolysaccharides aimed tosee if GAAE had an anti-inflammatory impact on human …