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Cognitive Neuroscience

Howard Casey Cromwell

Selected Works

Articles 1 - 3 of 3

Full-Text Articles in Life Sciences

Effects Of Anandamide Administration On Components Of Reward Processing, Howard C. Cromwell May 2017

Effects Of Anandamide Administration On Components Of Reward Processing, Howard C. Cromwell

Howard Casey Cromwell

Previous research has implicated the positive modulation of anandamide, an endocannabinoid neurotransmitter,on feeding behavior. Anandamide is particularly noteworthy as it acts as an endogenous ligand of the CB1receptor, the same receptor that is activated by tetrahydrocannabinol, the primary psychoactive component in Cannabis sativa. Cannabis legalization in North America has presented with a need to study endocannabinoid agonists and their effects on behavior. Much has yet to be determined in terms of the role of the endocannabinoid system in decision-making scenarios. The research presented here tested the hypothesis that anandamide wouldaugment motivation and reward processing via appetitive and …

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Cromwell Relative Reward Striatal Activity.Pdf, Howard C. Cromwell, Emily S. Webber, David E. Mankin Sep 2016

Cromwell Relative Reward Striatal Activity.Pdf, Howard C. Cromwell, Emily S. Webber, David E. Mankin

Howard Casey Cromwell

The striatum is a key brain region involved in reward processing. Striatal activity has been linked to encoding rewardmagnitude and integrating diverse reward outcome information. Recent work has supported the involvement ofstriatum in the valuation of outcomes. The present work extends this idea by examining striatal activity during dynamicshifts in value that include different levels and directions of magnitude disparity. A novel task was used to produce
diverse relative reward effects on a chain of instrumental action. Rats (Rattus norvegicus) were trained to respond to
cues associated with specific outcomes varying by food pellet magnitude. Animals were exposed …

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Influence Of Perinatal Exposure To A Polychlorinated Biphenyl Mixture On Learning And Memory, Hippocampal Size, And Estrogen Receptor-Beta Expression, Howard Cromwell Dec 2009

Influence Of Perinatal Exposure To A Polychlorinated Biphenyl Mixture On Learning And Memory, Hippocampal Size, And Estrogen Receptor-Beta Expression, Howard Cromwell

Howard Casey Cromwell

Abstract. Perinatal exposure to PCB has been reported to cause a variety of health effects including endocrine disruption, and immunologic, reproductive, neurologic, and behavioral deficits. In the present study, a mixture of two PCB congeners, one non-coplanar (PCB 47) and one coplanar (PCB 77), were administered to young female Sprague-Dawley rats by route of maternal dietary consumption (either 12.5 ppm or 25.0 ppm, w/w). Impact on learning and memory were examined by radial arm maze on postnatal day 24-27. After behavioral tests were completed, the rats were transcardially perfused, and brains were excised. Immunohistochemistry for ER- β was carried out …

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