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Mechanism Of Gene Regulation By Coding Polya Tracks, Laura Lea Arthur
Mechanism Of Gene Regulation By Coding Polya Tracks, Laura Lea Arthur
Arts & Sciences Electronic Theses and Dissertations
Regulation of gene expression is essential for cellular development and survival. The great variety and complexity of regulatory mechanisms underscores this fact. Messenger RNA stability and translational efficiency are often key determinants of gene expression. mRNA surveillance pathways, discovered for their role in degradation of aberrant mRNA, are now known to be instrumental in the regulation of physiologically correct mRNA stability. Thus, the study of cis elements in a transcript that can induce mRNA surveillance pathways has become an area of particular interest.
Here I report on the mechanism of gene regulation by coding polyA tracks, defined as a sequence …