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Structural And Functional Evaluation Of C. Elegans Filamins Fln-1 And Fln-2, Christina R. Demaso, Ismar Kovacevic, Alper Uzun, Erin J. Cram
Structural And Functional Evaluation Of C. Elegans Filamins Fln-1 And Fln-2, Christina R. Demaso, Ismar Kovacevic, Alper Uzun, Erin J. Cram
Erin Cram
Filamins are long, flexible, multi-domain proteins composed of an N-terminal actin-binding domain (ABD) followed by multiple immunoglobulin-like repeats (IgFLN). They function to organize and maintain the actin cytoskeleton, to provide scaffolds for signaling components, and to act as mechanical force sensors. In this study, we used transcript sequencing and homology modeling to characterize the gene and protein structures of the C. elegans filamin orthologs fln-1 and fln-2. Our results reveal that C. elegans FLN-1 is well conserved at the sequence level to vertebrate filamins, particularly in the ABD and several key IgFLN repeats. Both FLN-1 and the more divergent FLN-2 …