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Zinc Oxide Nanoparticles As Potential Novel Anticancer Therapies, Janet C. Layne
Zinc Oxide Nanoparticles As Potential Novel Anticancer Therapies, Janet C. Layne
Boise State University Theses and Dissertations
Nanoparticles (NP) are increasingly being recognized for their utility in the field of medicine, including use as drug carriers and imaging tools. We demonstrated that ZnO NP preferentially kill cancerous cells of the T cell lineage, and extended this research to evaluate other cells types, including normal and malignant B cells, and normal and malignant breast and prostate epithelial cells. Preferential ZnO nanoparticle cytotoxicity occurred for multiple types of cancer cells, but was most pronounced for non-adherent cells of hematopoietic lineage. Normal T and B lymphocytes showed the greatest resistance to NP toxicity, followed by normal breast epithelial cells, and …