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Sodium Channel Γenac Mediates Il-17 Synergized High Salt Induced Inflammatory Stress In Breast Cancer Cells, Suneetha Amara, Michael T. Ivy, Elbert L. Myles, Venkataswarup Tiriveedhi
Sodium Channel Γenac Mediates Il-17 Synergized High Salt Induced Inflammatory Stress In Breast Cancer Cells, Suneetha Amara, Michael T. Ivy, Elbert L. Myles, Venkataswarup Tiriveedhi
Biology Faculty Research
Chronic inflammation is known to play a critical role in the development of cancer. Recent evidence suggests that high salt in the tissue microenvironment induces chronic inflammatory milieu. In this report, using three breast cancer-related cell lines, we determined the molecular basis of the potential synergistic inflammatory effect of sodium chloride (NaCl) with interleukin-17 (IL-17). Combined treatment of high NaCl (0.15M) with sub-effective IL-17 (0.1nM) induced enhanced growth in breast cancer cells along with activation of reactive nitrogen and oxygen (RNS/ROS) species known to promote cancer. Similar effect was not observed with equi-molar mannitol. This enhanced of ROS/RNS activity correlates …