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Full-Text Articles in Life Sciences
Mfge8 Regulates Tgf-Β-Induced Epithelial Mesenchymal Transition In Endometrial Epithelial Cells In Vitro, Liang Yu, Rong Hu, Claretta Sullivan, R. James Swanson, Sergio Oehninger, Ying-Pu Sun, Silvina Bocca
Mfge8 Regulates Tgf-Β-Induced Epithelial Mesenchymal Transition In Endometrial Epithelial Cells In Vitro, Liang Yu, Rong Hu, Claretta Sullivan, R. James Swanson, Sergio Oehninger, Ying-Pu Sun, Silvina Bocca
Biological Sciences Faculty Publications
This study investigated the role of milk fat globule-epidermal growth factor-factor 8 (MFGE8) in TGF-β-induced epithelial– mesenchymal transition (EMT) of endometrial epithelial cells. These were in vitro studies using human endometrial epithelial cells and mouse blastocysts. We investigated the ability of TGF-β to induce EMT in endometrial epithelial cells (HEC-1A) by assessment of cytological phenotype (by light and atomic force microscopy), changes in expression of the markers of cell adhesion/differentiation E- and N-cadherin, and of the transcription factor Snail (by immunofluorescence and immunoblotting), and competence to support embryo attachment in a mouse blastocyst outgrowth assay. We also studied the effects …