Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Cadaver (2)
- Humectant (2)
- Preservation (2)
- Anatomy (1)
- Beta-cell death (1)
-
- Cancer (1)
- Ceramide (1)
- Claudin (1)
- Developmental defects (1)
- Diabetes (1)
- Dopamine and ATP Microglial Motility (1)
- Exercise (1)
- Gene expression (1)
- Glucolipotoxicity (1)
- Immunocompromised (1)
- Jaspine B (1)
- Junctional adhesion molecule (JAM) (1)
- Ketogetic diet (1)
- Ketones (1)
- Metabolites (1)
- Mitochondrial efficiency (1)
- Multiple sclerosis (1)
- Neural Tube Defects (1)
- Non-stem cells (1)
- Percussive massage (1)
- Pro-inflammatory cytokines (1)
- Sarcoma (1)
- Skin (1)
- Sphingomyelin Synthase (1)
- Stem cells (1)
Articles 1 - 11 of 11
Full-Text Articles in Life Sciences
The Effect Of Epicatechin And Its Microbial Metabolites On Differing Pathways Of Beta-Cell Death In Type I And Type Ii Diabetes, Aubree Bench, Jeffery S. Tessem
The Effect Of Epicatechin And Its Microbial Metabolites On Differing Pathways Of Beta-Cell Death In Type I And Type Ii Diabetes, Aubree Bench, Jeffery S. Tessem
Library/Life Sciences Undergraduate Poster Competition 2024
The pathogenesis of type 1 (T1D) and type 2 diabetes (T2D) is associated with progressive beta-cell death and loss of insulin secretion, making functional betacell mass preservation a priority in the treatment of diabetes. T1D beta-cell death is primarily mediated by autoimmune exposure of beta-cells to proinflammatory cytokines such as IL-1b, TNFa, and IFNg (1, 2). Beta-cell loss in T2D, however, is characterized by damage caused by a destructive metabolic state of persistent hyperglycemia and elevated free fatty acid (FFA) levels (2, 3). Our lab has shown that the monomeric flavonoid epicatechin and its metabolites hippuric acid, homovanillic acid, and …
The Effect Of Percussive Massage On Collagen Gene Expression In Skeletal Muscle, James Bartling, Robert D. Hyldahl, Emma Schaugaard, Mohadeseh Ahmadi
The Effect Of Percussive Massage On Collagen Gene Expression In Skeletal Muscle, James Bartling, Robert D. Hyldahl, Emma Schaugaard, Mohadeseh Ahmadi
Library/Life Sciences Undergraduate Poster Competition 2024
INTRODUCTION
• Exercise is a critical aspect of healthy living due in part to its effects of muscle adaptation, which are largely regulated by alterations in gene expression
• Sedentary behavior can be required by diverse life circumstances, suggesting a need to reproduce the beneficial effects of exercise by an alternative means
• Like exercise, percussive massage introduces a mechanical strain on the muscle, which could potentially replicate a similar remodeling response of the extracellular matrix (ECM). However, this has not yet been studied
• Collagen 1,3,&4 are major components of the ECM that adapt in response to exercise, and …
Staying Hydrated: A Comparative Analysis Of Humectants In Human Tissue, Rachel Prince, Jason Adams, Joseph Monsen
Staying Hydrated: A Comparative Analysis Of Humectants In Human Tissue, Rachel Prince, Jason Adams, Joseph Monsen
Library/Life Sciences Undergraduate Poster Competition 2024
3rd Place Poster Design
Humectants are an important class of compounds that attract and retain water within a cell. When mixed with water to create wetting solutions, humectants can prevent desiccation of cadaveric specimens1. Recognizing a relative scarcity of comparative studies analyzing the effects of various wetting solutions on post-preservation cadaveric maintenance, we utilized wet-dry analysis in order to compare the effects of four common humectants on water retention in human cadaveric tissue including brain, cardiac muscle, liver, lung, skeletal muscle, and skin. We created a concentration gradient for each humectant to identify the optimal concentrations of each compound for …
Jaspine B And The Sea Sponge That Fights Cancer, Jack Davis, Jared Barrott, Adriene Pavek, Farjana Afrin, Sameena Mateen, Brendon Meldrum, Rocio Rojas, Pamela Diaz, Megan Condie, Ali Aghazadeh-Habashi, Srinath Pashikanti
Jaspine B And The Sea Sponge That Fights Cancer, Jack Davis, Jared Barrott, Adriene Pavek, Farjana Afrin, Sameena Mateen, Brendon Meldrum, Rocio Rojas, Pamela Diaz, Megan Condie, Ali Aghazadeh-Habashi, Srinath Pashikanti
Library/Life Sciences Undergraduate Poster Competition 2024
Jaspine B is a natural marine product, derived from the sea sponge, Jaspis, found in some tropical climates. Jaspine B has been shown to be an effective treatment in some cancers with an upregulation of sphingomyelin synthase. This research aimed to understand the effects of Jaspine B on synovial sarcoma, and investigate its potential to be used as targeted treatment in other cancers that have an upregulation of sphingomyelin synthase
Exploring The Role Of Dopamine And Atp In Microglial Motility, Derek Langford, Jordan Yorgas, Christopher Galbraith, Channing Syme, Brayden Parker, Savannah Evans, Derek Langford, Eliza White, Erin Taylor, Lauren Ford, Hillary Wadsworth
Exploring The Role Of Dopamine And Atp In Microglial Motility, Derek Langford, Jordan Yorgas, Christopher Galbraith, Channing Syme, Brayden Parker, Savannah Evans, Derek Langford, Eliza White, Erin Taylor, Lauren Ford, Hillary Wadsworth
Library/Life Sciences Undergraduate Poster Competition 2024
►Recent studies from our laboratory have identified that dopamine and ATP in the Nucleus Accubmens (NAc) are co-released.
►ATP is a chemoattractant for macrophages in general, and microglia specifically, suggesting that dopamine and ATP corelease may function to alter microglia activity.
►The present work characterizes the effects of microglia activation via lipopolysaccharide (LPS) on dopamine terminal function, and the effects of dopamine and ATP on microglia motility.
Chimeric Claudins Reveal Role In Neural Tube Defects, Wesley Allen, Nathan Beckett, Emma Brenchley, Jacob Wengler, Lauren Hall, Cailey Winn, Meredith Mann, Sion Jung, Spencer Thacker, Rachel May, Dario Mizrachi, Micheal Stark
Chimeric Claudins Reveal Role In Neural Tube Defects, Wesley Allen, Nathan Beckett, Emma Brenchley, Jacob Wengler, Lauren Hall, Cailey Winn, Meredith Mann, Sion Jung, Spencer Thacker, Rachel May, Dario Mizrachi, Micheal Stark
Library/Life Sciences Undergraduate Poster Competition 2022
Claudins (CLDN), a family of proteins found in the tight junction, play a major role in membrane permeability. While claudin disruption is known to contribute to the formation of neural tube defects (NTD), current research methods rely heavily on a non-specific toxin, CPE, when exploring the importance of CLDNs within neural tube formation. This makes it difficult to identify individual CLDN’s contribution to NTD formation, creating a need for a more specific method.
Staying Hydrated: A Comparative Analysis Of Humectants In Human Skin, Ayden Olsen, Rachel Prince, Craig Reeves, Cassie Peterson, Jason Adams
Staying Hydrated: A Comparative Analysis Of Humectants In Human Skin, Ayden Olsen, Rachel Prince, Craig Reeves, Cassie Peterson, Jason Adams
Library/Life Sciences Undergraduate Poster Competition 2022
Humectants are an important class of compounds that attract and retain water within a cell. When mixed with water to create wetting solutions, humectants can prevent desiccation of cadaveric specimens. Recognizing a relative scarcity of comparative studies analyzing the effects of various wetting solutions on post preservation cadaveric maintenance, we utilized wet-dry analysis in order to compare the effects of four common humectants on water retention in human skin tissue. We created a concentration gradient for each humectant to identify the optimal concentrations of each compound for water retention, after which we compared water retention in tissue at the optimal …
New Treatment For Multiple Sclerosis Could Halt Disease Progression Without Weakening Immune System, Carter Helquist, Dario Mizrachi
New Treatment For Multiple Sclerosis Could Halt Disease Progression Without Weakening Immune System, Carter Helquist, Dario Mizrachi
Library/Life Sciences Undergraduate Poster Competition 2022
- Multiple Sclerosis (MS) is a debilitating neurological and autoimmune disease in which immune cells cause demyelination of axons in nervous tissue.
- Current treatments for the disease are principally aimed at weakening the immune system to therefore weaken the autoimmune attack on the brain. This leaves patients prone to other sicknesses.
- We seek a treatment that prevents the immune cells from entering the central nervous system (CNS) thereby protecting its cells.
- We can prevent immune cells from entering the CNS by strengthening the blood brain barrier through targeting claudin 5 proteins in the tight junctions.
- This new treatment could mean increased …
A Ketogenic Diet Enhances Hippocampal Mitochondrial Efficiency, Cali E. Warren, Erin R. Saito, Benjamin T. Bikman
A Ketogenic Diet Enhances Hippocampal Mitochondrial Efficiency, Cali E. Warren, Erin R. Saito, Benjamin T. Bikman
Library/Life Sciences Undergraduate Poster Competition 2022
Mitochondrial dysfunction and cognitive impairment are common symptoms in many neurologic disorders, as well as in nonpathological aging. Ketones have been suggested as therapeutic for their relevance in epilepsy and other neurodegenerative diseases and psychiatric disorders such as Alzheimer’s and Parkinson’s disease, schizophrenia, and major depressive disorder.
Interruption Of Junctional Adhesion Molecules Shows Developmental Defects, Wesley Allen, Nathan Beckett, Lauren Hall, Emma Holdaway, Sion Jung, Meredith Mann, Spencer Thacker, Jacob Wengler, Cailey Winn, Dario Mizrachi, Michael Stark
Interruption Of Junctional Adhesion Molecules Shows Developmental Defects, Wesley Allen, Nathan Beckett, Lauren Hall, Emma Holdaway, Sion Jung, Meredith Mann, Spencer Thacker, Jacob Wengler, Cailey Winn, Dario Mizrachi, Michael Stark
Library/Life Sciences Undergraduate Poster Competition 2022
Development of the central nervous system, the brain and the spinal cord, starts initially with the formation of the neural tube. This vital process starts as a sheet of cells which then folds into a cylindrical structure in the early stages of embryo development (Fig1). Defects in the formation of the neural tube can lead to permanent disabilities in babies after birth. This is important to understand as current statistics show that approximately 300,000 babies are born annually with neural tube defects. (NTDs). In addition to NTDs there are many other dangerous birth defects that are important to understand as …
Using Non Stem-Cells To Understand Early Tumor Growth, Jake Hogan, Heiko Enderling, Joel Brown, Robert A. Gatenby
Using Non Stem-Cells To Understand Early Tumor Growth, Jake Hogan, Heiko Enderling, Joel Brown, Robert A. Gatenby
Library/Life Sciences Undergraduate Poster Competition 2018
Tumors of similar size and shape can exhibit different responses to the same treatment. Targeted therapy aims to better treat these tumors by classifying them according to genotypic traits. A better understanding of how tumor traits such as non-stem cells influence tumor growth could improve targeted therapy. We hypothesize that the production of non-stem cells may aid tumor growth in avascular tumors (tumors lacking blood vessels).