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Stress-Induced Proteolysis Of Fkbp10: Mutational Analysis And Functional Implications, Lindsey A. Murphy
Stress-Induced Proteolysis Of Fkbp10: Mutational Analysis And Functional Implications, Lindsey A. Murphy
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Cellular signaling is a complex system of communication that regulates cell function through a variety of molecular messengers. When cell survival is threatened by changes in environment or by malfunction of internal regulatory pathways, signals are initiated to restore homeostasis. Deficient protein processing within the endoplasmic reticulum (ER) causes an accumulation of misfolded proteins and stress signaling. The resulting stress signaling includes both adaptive signals (unfolded protein response) and in cases of severe ER stress apoptotic signals induced via the mitochondria. FKBP10 is a key ER luminal peptidy-prolyl isomerase (rotamase) that mediates protein folding. The production of chaperone proteins and …