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Touro College and University System
Aging; Geroprevention; Growth hormone; HSCs; Insulin; Insulin-like growth factor; Longevity; Parental imprinting; VSELs
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Full-Text Articles in Life Sciences
Prolonged Growth Hormone/Insulin/Insulin-Like Growth Factor Nutrient Response Signaling Pathway As A Silent Killer Of Stem Cells And A Culprit In Aging, Mariusz Ratajczak, Andrzej Bartke, Zbigniew Darzynkiewicz
Prolonged Growth Hormone/Insulin/Insulin-Like Growth Factor Nutrient Response Signaling Pathway As A Silent Killer Of Stem Cells And A Culprit In Aging, Mariusz Ratajczak, Andrzej Bartke, Zbigniew Darzynkiewicz
NYMC Faculty Publications
The dream of slowing down the aging process has always inspired mankind. Since stem cells are responsible for tissue and organ rejuvenation, it is logical that we should search for encoded mechanisms affecting life span in these cells. However, in adult life the hierarchy within the stem cell compartment is still not very well defined, and evidence has accumulated that adult tissues contain rare stem cells that possess a broad trans-germ layer differentiation potential. These most-primitive stem cells-those endowed with pluripotent or multipotent differentiation ability and that give rise to other cells more restricted in differentiation, known as tissue-committed stem …