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Regulation Of E2f1 In Keratinocytes During Uv-Damage And Differentiation, Randeep K. Singh
Regulation Of E2f1 In Keratinocytes During Uv-Damage And Differentiation, Randeep K. Singh
Electronic Thesis and Dissertation Repository
The E2F1 transcription factor regulates the expression of key genes involved in cell proliferation and differentiation to maintain skin homeostasis. The expression of E2F1 is tightly regulated during cell cycle progression and when cells are committed to differentiate, as well as in response to DNA damage. In keratinocytes, E2F1 protein and transcript levels increase following UV-induced DNA damage, whereas, in response to Ca2+-induced differentiation, both E2F1 protein and transcript levels decrease. In this thesis, I examined in detail the mechanism that modulates E2F1 stability following DNA damage and during keratinocyte differentiation. I show that E2F1 associates with hHR23 and together …