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Full-Text Articles in Life Sciences
Profiling The Macrofilaricidal Effects Of Flubendazole On Adult Female Brugia Malayi Using Rnaseq, Maeghan O'Neill, Cristina Ballesteros, Lucienne Tritten, Erica Burkman, Weam I. Zaky, Jianguo Xia, Andrew Moorhead, Steven A. Williams, Timothy G. Geary
Profiling The Macrofilaricidal Effects Of Flubendazole On Adult Female Brugia Malayi Using Rnaseq, Maeghan O'Neill, Cristina Ballesteros, Lucienne Tritten, Erica Burkman, Weam I. Zaky, Jianguo Xia, Andrew Moorhead, Steven A. Williams, Timothy G. Geary
Biological Sciences: Faculty Publications
The use of microfilaricidal drugs for the control of onchocerciasis and lymphatic filariasis (LF) necessitates prolonged yearly dosing. Prospects for elimination or eradication of these diseases would be enhanced by the availability of a macrofilaricidal drug. Flubendazole (FLBZ), a benzimidazole anthel- mintic, is an appealing candidate. FLBZ has demonstrated potent macrofilaricidal effects in a number of experimental rodent models and in one human trial. Unfortunately, FLBZ was deemed unsatisfactory for use in mass drug administration campaigns due to its limited oral bioavailability. A new formulation that enables sufficient bioavailability following oral administration could render FLBZ an effective treatment for onchocerciasis …
Stable Isotopes And The Ecology And Physiology Of Reptiles, Andrew M. Durso
Stable Isotopes And The Ecology And Physiology Of Reptiles, Andrew M. Durso
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
When animals don’t have enough food, they have to “choose” between “spending” their limited energy on themselves or on their offspring. Biologists think that reptiles can make this choice quickly in response to different environments. But, it can be hard to study these choices because it is hard to convert between, for example, the number of eggs laid and the speed of healing a wound. By using stable isotope chemistry, we can collect more detailed and comparable information about how lizards and other animals spend their limited resources than with any other method. For example, lizards in the wild have …
Effects Of Researcher-Induced Disturbance On American Kestrels Breeding In Nest Boxes In Northwestern New Jersey, John Smallwood
Effects Of Researcher-Induced Disturbance On American Kestrels Breeding In Nest Boxes In Northwestern New Jersey, John Smallwood
Department of Biology Faculty Scholarship and Creative Works
Nest boxes for American Kestrels Falco sparverius may alleviate local nest site limitation, but there is concern that periodically opening nest boxes or handling adults may negatively affect nesting success. I monitored 536 kestrel breeding attempts ≥1 egg laid in about 100 nest boxes in northwestern New Jersey, 1995-2012. To study return rates, I opportunistically captured adults in nest boxes and marked them with U.S.G.S. leg bands and patagial tags. To examine possible effects of this disturbance, I compared nesting success ≥1 nestling surviving to banding age of marked and unmarked adults. Nesting success was 67% for 270 unmarked pairs, …
Macgillivray's Seaside Sparrow (Ammodramus Maritimus Macgillivraii) Breeding Biology & Population Density At Tom Yawkey Wildlife Center, Yianni P. Laskaris
Macgillivray's Seaside Sparrow (Ammodramus Maritimus Macgillivraii) Breeding Biology & Population Density At Tom Yawkey Wildlife Center, Yianni P. Laskaris
Electronic Theses and Dissertations
MacGillivray's Seaside Sparrow (Ammodramus maritimus macgillivraii) is a coastal marsh species sensitive to habitat alteration and threatened by coastal wetland loss. Data on seaside sparrow distribution, breeding success, and critical habitats are lacking in South Carolina. To better understand the demographics and incubation behavior of the species, I monitored breeding success, densities, song output, and presence of predators at three 7-hectare plots at the densest known population in the state. I also placed temperature data-loggers in a subset of nests to discern any links between incubation behavior and nest fate. Densities varied from a low of 5 birds/ha in a …
Neural And Neuroendocrine Processing Of A Non-Photic Cue In An Opportunistically Breeding Songbird, Darcy K. Ernst, G. E. Bentley
Neural And Neuroendocrine Processing Of A Non-Photic Cue In An Opportunistically Breeding Songbird, Darcy K. Ernst, G. E. Bentley
Biology Faculty Publications
Recent studies of the onset of breeding in long-day photoperiodic breeders have focused on the roles of type 2 and 3 iodothyronine deiodinases (DIO2 and DIO3) in the conversion of thyroxine (T4) to triiodothyronine (T3) and subsequent activation of the reproductive axis. It has been hypothesized that an increase in DIO2 and a reciprocal decrease in DIO3 causes the release of gonadotropinreleasing hormone (GnRH) from the hypothalamus, setting off a reproductive cascade, and that this DIO mechanism for GnRH release is conserved across vertebrate taxa. We sought to test whether social cues that are known to stimulate reproductive behaviors can …
Evidence Of Female Sex Pheromones And Characterization Of The Cuticular Lipids Of Unfed, Adult Male Versus Female Blacklegged Ticks, Ixodes Scapularis, Ann L. Carr, Daniel E. Sonenshine, John B. Strider Jr., R. Michael Roe
Evidence Of Female Sex Pheromones And Characterization Of The Cuticular Lipids Of Unfed, Adult Male Versus Female Blacklegged Ticks, Ixodes Scapularis, Ann L. Carr, Daniel E. Sonenshine, John B. Strider Jr., R. Michael Roe
Biological Sciences Faculty Publications
Copulation in I. scapularis involves physical contact between the male and female (on or off the host), male mounting the female, insertion/maintenance of the male chelicerae in the female genital pore (initiates spermatophore production), and the transfer of the spermatophore by the male into the female genital pore. Bioassays determined that male mounting behavior/chelicerae insertion required direct contact with the female likely requiring non-volatile chemical cues with no evidence of a female volatile sex pheromone to attract males. Unfed virgin adult females and replete mated adult females elicited the highest rates of male chelicerae insertion with part fed virgin adult …