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Characterization Of Transepithelial Potential Oscillations In The Drosophila Malpighian Tubule, Edward M. Blumenthal
Characterization Of Transepithelial Potential Oscillations In The Drosophila Malpighian Tubule, Edward M. Blumenthal
Biological Sciences Faculty Research and Publications
The Malpighian tubule of Drosophila melanogaster is a useful model system for studying the regulation of epithelial ion transport. In acutely isolated tubules, the transepithelial potential (TEP) undergoes large oscillations in amplitude with a period of approximately 30s. The TEP oscillations are diminished by reductions in the peritubular chloride concentration in a manner consistent with their being caused by fluctuations in chloride conductance. The oscillations are eliminated by pretreating tubules with the calcium chelator BAPTA-AM, although removal of peritubular calcium has no effect, suggesting that the oscillations are a result of either the release of calcium from intracellular stores or …