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In Vitro Identification Of The Effect Of Serotonin On Lymphocyte Dna Synthesis And Natural Killer Cell Activity, Kim Kartchener Kane
In Vitro Identification Of The Effect Of Serotonin On Lymphocyte Dna Synthesis And Natural Killer Cell Activity, Kim Kartchener Kane
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
The purpose of this study was to identify the effects of the neurotransmitter, serotonin (SE), on the immune function of peripheral blood mononuclear cells (PBMC) of normal, healthy subjects. This was done as a preliminary investigation to studies on the association of SE with immune changes in autistic subjects.
The PBMC isolated from normal male subjects were treated with various concentrations of SE for 48 hrs. Their incubation in SE at a concentration of 10-3 M induced about a 35% decrease in DNA synthesis. However, incubation of the cells in lower concentrations (10-4 to 10-10) of …