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An Investigation Into The Adiponectin Receptor Levels In Cardiac, Liver And Skeletal Muscle Of Mature Rats., Jacqueline Sippel
An Investigation Into The Adiponectin Receptor Levels In Cardiac, Liver And Skeletal Muscle Of Mature Rats., Jacqueline Sippel
College of Arts & Sciences Senior Honors Theses
Both obesity and diabetes are domestic and international health problems. Adiponectin is a protein secreted from adipocytes and other tissues such as muscle which influences carbohydrate and lipid metabolism. For this reason, Adiponectin is a primary target for therapeutic treatment of metabolic diseases. Adiponectin interacts with receptors termed AdipoR1 and AdipoR2, which are structurally similar to G protein-coupled receptors except with a reverse membrane topology. The aim of this study is to determine the levels of AdipoR1 and AdipoR2 within cardiac, skeletal, and liver tissue samples of mature non-obese rats. The objective of determining potential differences in the tissue levels …