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The Human Immune Response To The Flagellins Of Burkholderia Dolosa., Molly Mcdonald
The Human Immune Response To The Flagellins Of Burkholderia Dolosa., Molly Mcdonald
College of Arts & Sciences Senior Honors Theses
Cystic Fibrosis (CF) is the most commonly inherited lethal disorder in Caucasian populations. Chronic bacterial infection both decreases lung function and lowers the quality of the CF patient’s life. In one of the most recent CF epidemics, Burkholderia dolosa, an organism previously uncharacterized as an epidemic strain, infected over forty patients and led to the death of over seven patients at Children’s Hospital Boston. Preliminary research revealed that this strain of B. dolosa possesses genes for two distinct types of flagella, which is uncommon in bacterial pathogens. In this study we examine the interaction of human cells and B. dolosa, …