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Pparγ And High Molecular Weight Adiponectin In White Adipose Tissue In An Obesity Model., Katelyn M. Mcdowell
Pparγ And High Molecular Weight Adiponectin In White Adipose Tissue In An Obesity Model., Katelyn M. Mcdowell
College of Arts & Sciences Senior Honors Theses
Adiponectin is a protein secreted from adipose (fat) tissue. It is secreted into the blood as either a trimer (low molecular weight), hexamer (middle molecular weight) or an 18-mer (high molecular weight). Adiponectin, particularly the high molecular weight (HMW) isoform, has been shown to increase insulin sensitivity, which is important for maintaining healthy blood glucose levels. Adiponectin levels have been shown to be decreased in individuals who are obese, and this may play a role in the diabetes which often accompanies obesity. PPARγ is a protein that is highly expressed in white adipose tissue and is responsible for regulating portions …