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Biology

College of Arts & Sciences Senior Honors Theses

Adiponectin

Publication Year

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Full-Text Articles in Life Sciences

Dsba-L Protein Levels In White Adipose Tissue In An Obesity Model., Madison E. Kerley May 2018

Dsba-L Protein Levels In White Adipose Tissue In An Obesity Model., Madison E. Kerley

College of Arts & Sciences Senior Honors Theses

Adiponectin is an adipose tissue-secreted protein found in three isoforms. Disulfide bond A oxidoreductase-like protein (DsbA-L) is thought to assist with protomeric disulfide bonding to generate the HMW (high molecular weight) isoform, which regulates insulin sensitivity. Both adiponectin and DsbA-L were previously found to negatively correlate with obesity.

Immunoblots were conducted on adipose tissue samples from male mice fed a high or low-fat diet for 6, 10, or 16 weeks. Immunoblots from high-fat diet-fed mice revealed double bands for DsbA-L. High and low molecular weight bands were analyzed together, revealing significantly higher relative band densities with 10 and 16-week high-fat …


Habitat Effects On Blood Adiponectin Isoforms In Black Bears., James-Dean Wood May 2016

Habitat Effects On Blood Adiponectin Isoforms In Black Bears., James-Dean Wood

College of Arts & Sciences Senior Honors Theses

No abstract provided.