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Full-Text Articles in Life Sciences
The Effects Of Ppal-1 In Arabidopsis Gamete Development., Amanda White
The Effects Of Ppal-1 In Arabidopsis Gamete Development., Amanda White
College of Arts & Sciences Senior Honors Theses
Prenylation is a type of post-translational modification in which a 15- or 20-carbon lipid is added to the carboxyl (C) terminus of the protein. Arabidopsis thaliana contains the PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT-LIKE (PPAL) gene, which encodes a protein with homology to the α-subunits of the three known prenylation enzymes, PFT, PGGT, and Rab-GGT. We previously identified two mutations in PPAL, one of which is ppal-1, which contains a T-DNA insertion in the fourth intron. We have previously observed that self-fertilizing heterozygous ppal-1 plants produce progeny in which homozygous ppal-1 is underrepresented. This project attempts to ascertain …
Phytochemical Content And Anti-Breast Cancer Activity Of Kentucky Native Plants., Nicole A. Mcgrath
Phytochemical Content And Anti-Breast Cancer Activity Of Kentucky Native Plants., Nicole A. Mcgrath
College of Arts & Sciences Senior Honors Theses
Plants are a proven and rich source of chemical diversity for the development of pharmaceuticals. Plants that are native to Kentucky are an underexplored resource that could lead to advances in treating human diseases such as cancer. Kentucky native plants, especially those with highly diverse or enriched chemical compositions are possible leads for therapeutic drug development. To explore the potential of native Kentucky plants for treatment of breast cancer, a list of prospective target plants was developed based on literature reports. This list was narrowed to 10 tissues for further in-depth chemical analysis including estimation of alkaloids, terpenes, and phenolics, …