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Full-Text Articles in Life Sciences
Identification And Expression Analysis Of Sugar Transporters In Microbotryum Violaceum., Jared Morris Andrews
Identification And Expression Analysis Of Sugar Transporters In Microbotryum Violaceum., Jared Morris Andrews
College of Arts & Sciences Senior Honors Theses
No abstract provided.
Epidemiology And Virulence Of Clostridium Difficile : An Evolutionary Perspective., Lindsey E. Hastings
Epidemiology And Virulence Of Clostridium Difficile : An Evolutionary Perspective., Lindsey E. Hastings
College of Arts & Sciences Senior Honors Theses
The emergence of virulent, antibiotic-resistant Clostridium difficile ribotypes over the past thirty years has greatly concerned both the medical and research communities. As of 2010, C. difficile has surpassed methicillin-resistant Staphylococcus aureus (MRSA) as a cause of nosocomial infections and is now found in both healthcare settings and outside communities in the United States. Attendant-borne transmission in hospitals has been associated with the evolution of increased virulence in other nosocomial pathogens, but evolutionary theory has yet to be applied to the epidemiology and virulence of C. difficile. Differences between nosocomial C. difficile infections (CDI) and community-associated CDI (CA-CDI) mortality and …
Interactions Between Human Neutrophils And Mycobacterium Smegmatis : A Comparative General Analysis., Irina Miralda
Interactions Between Human Neutrophils And Mycobacterium Smegmatis : A Comparative General Analysis., Irina Miralda
College of Arts & Sciences Senior Honors Theses
Mycobacteria smegmatis is an abundant soil and water inhabitant with which humans are continuously in contact. Despite the fact that it is typically considered non-‐pathogenic, a few rare cases of M. smegmatis-‐caused infections have been reported and it has been shown that M. smegmatis is able to modulate inflammatory responses in macrophages. Neutrophils are the innate immune system’s first line of centralized defense against invading microbes, especially the frequently encountered M. smegmatis. However, very little information is known of the mechanism by which neutrophils eliminate environmental bacteria. In this study, the hypothesis that M. smegmatis regulates neutrophil functional responses, and …
The Human Immune Response To The Flagellins Of Burkholderia Dolosa., Molly Mcdonald
The Human Immune Response To The Flagellins Of Burkholderia Dolosa., Molly Mcdonald
College of Arts & Sciences Senior Honors Theses
Cystic Fibrosis (CF) is the most commonly inherited lethal disorder in Caucasian populations. Chronic bacterial infection both decreases lung function and lowers the quality of the CF patient’s life. In one of the most recent CF epidemics, Burkholderia dolosa, an organism previously uncharacterized as an epidemic strain, infected over forty patients and led to the death of over seven patients at Children’s Hospital Boston. Preliminary research revealed that this strain of B. dolosa possesses genes for two distinct types of flagella, which is uncommon in bacterial pathogens. In this study we examine the interaction of human cells and B. dolosa, …