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Avoidance Of Apoptosis In Embryonic Cells Of The Annual Killifish Austrofundulus Limnaeus Exposed To Anoxia, Camie Lynn Meller, Jason E. Podrabsky
Avoidance Of Apoptosis In Embryonic Cells Of The Annual Killifish Austrofundulus Limnaeus Exposed To Anoxia, Camie Lynn Meller, Jason E. Podrabsky
Biology Faculty Publications and Presentations
Embryos of the annual killifish Austrofundulus limnaeus have unequalled ability among vertebrates to survive long-term anoxia. Surprisingly, these embryos can survive for months in anoxia despite a large-scale decrease in ATP levels during the initial hours of anoxic exposure. These conditions are known to trigger apoptotic cell death in mammalian cells as a result of ischemia or anoxia. Anoxia-induced induction of apoptosis was investigated in four developmental stages of A. limnaeus that differ in their tolerance of anoxia, and thus may respond to anoxia uniquely. Exposure to staurosporine was used to determine if A. limnaeus cells were competent …