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Full-Text Articles in Life Sciences
Predominant And Substoichiometric Isomers Of The Plastid Genome Coexist Within Juniperus Plants And Have Shifted Multiple Times During Cupressophyte Evolution, Wenhu Guo, Felix Grewe, Amie Cobo-Clark, Weishu Fan, Zelin Duan, Robert P. Adams, Andrea E. Schwarzbach, Jeffrey P. Mower
Predominant And Substoichiometric Isomers Of The Plastid Genome Coexist Within Juniperus Plants And Have Shifted Multiple Times During Cupressophyte Evolution, Wenhu Guo, Felix Grewe, Amie Cobo-Clark, Weishu Fan, Zelin Duan, Robert P. Adams, Andrea E. Schwarzbach, Jeffrey P. Mower
Health & Biomedical Sciences Faculty Publications and Presentations
Most land plant plastomes contain two copies of a large inverted repeat (IR) that promote high-frequency homologous recombination to generate isomeric genomic forms. Among conifer plastomes, this canonical IR is highly reduced in Pinaceae and completely lost from cupressophytes. However, both lineages have acquired short, novel IRs, some of which also exhibit recombinational activity to generate genomic structural diversity. This diversity has been shown to exist between, and occasionally within, cupressophyte species, but it is not known whether multiple genomic forms coexist within individual plants. To examine the recombinational potential of the novel cupressophyte IRs within individuals and between species, …
Tuning Of Alternative Splicing - Switch From Proto-Oncogene To Tumor Suppressor, Aleksandra Shchelkunova, Boris Ermolinsky, Meghan Boyle, Ivan Mendez, Michael Lehker, Karen S. Martirosyan, Alexander V. Kazanksy
Tuning Of Alternative Splicing - Switch From Proto-Oncogene To Tumor Suppressor, Aleksandra Shchelkunova, Boris Ermolinsky, Meghan Boyle, Ivan Mendez, Michael Lehker, Karen S. Martirosyan, Alexander V. Kazanksy
Health & Biomedical Sciences Faculty Publications and Presentations
STAT5B, a specific member of the STAT family, is intimately associated with prostate tumor progression. While the full form of STAT5B is thought to promote tumor progression, a naturally occurring truncated isoform acts as a tumor suppressor. We previously demonstrated that truncated STAT5 is generated by insertion of an alternatively spliced exon and results in the introduction of an early termination codon. Present approaches targeting STAT proteins based on inhibition of functional domains of STAT's, such as DNA-binding, cooperative binding (protein-protein interaction), dimerization and phosphorylation will halt the action of the entire gene, both the proto-oncogenic and tumor suppressor functions …