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Full-Text Articles in Life Sciences
The Role Of Sos Boxes In Enteric Bacteriocin Regulation, Margaret Riley, Osnat Gillor, Jan A.C. Vriezen
The Role Of Sos Boxes In Enteric Bacteriocin Regulation, Margaret Riley, Osnat Gillor, Jan A.C. Vriezen
Margaret Riley
Bacteriocins are a large and functionally diverse family of toxins found in all major lineages of Bacteria. Colicins, those bacteriocins produced by Escherichia coli, serve as a model system for investigations of bacteriocin structure–function relationships, genetic organization, and their ecological role and evolutionary history. Colicin expression is often dependent on host regulatory pathways (such as the SOS system), is usually confined to times of stress, and results in death of the producing cells. This study investigates the role of the SOS system in mediating this unique form of toxin expression. A comparison of all the sequenced enteric bacteriocin promoters reveals …
Deciphering Evolutionary Mechanisms Between Mutualistic And Pathogenic Symbioses, Margaret Riley, M. K. Nishiguchi, A. M. Hirsch, R. Devinney, G. Vedantam, L. M. Mansky
Deciphering Evolutionary Mechanisms Between Mutualistic And Pathogenic Symbioses, Margaret Riley, M. K. Nishiguchi, A. M. Hirsch, R. Devinney, G. Vedantam, L. M. Mansky
Margaret Riley
The continuum between mutualistic and pathogenic symbioses has been an underlying theme for understanding the evolution of infection and disease in a number of eukaryotic-microbe associations. The ability to monitor and then predict the spread of infectious diseases may depend upon our knowledge and capabilities of anticipating the behavior of virulent pathogens by studying related, benign symbioses. For instance, the ability of a symbiotic species to infect, colonize, and proliferate efficiently in a susceptible host will depend on a number of factors that influence both partners during the infection. Levels of virulence are not only affected by the genetic and …