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The Biophysical Study Of The Efficacy Of Various Phospholipid Membranes On Daptomycin, Chaya Shor, Tamar Itzkowitz
The Biophysical Study Of The Efficacy Of Various Phospholipid Membranes On Daptomycin, Chaya Shor, Tamar Itzkowitz
The Science Journal of the Lander College of Arts and Sciences
Daptomycin is an important lipopeptide antibiotic used in the treatment of systematic and life-threatening infections of the skin and underlying tissue caused by Gram-positive bacteria. Calcium and phosphatidylglycerol (PG) must be present on the target cell membrane for daptomycin’s mechanism of action to proceed. Calcium and PG also promote oligomerization, a formation that has been assumed to aid in the bactericidal process. The purpose of the experiments conducted was to understand the basic biophysical properties of membrane phospholipids as they exist in their pure and mixed monolayer forms. Furthermore, the experiments conducted attempted to discern how daptomycin penetrates the different …