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Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
Investigating The Relationship Between Hormone Receptors Dax-1 And Estrogen Receptor Within Prostate Cancer Cell Lines, Meghana G. Vijayraghavan
Investigating The Relationship Between Hormone Receptors Dax-1 And Estrogen Receptor Within Prostate Cancer Cell Lines, Meghana G. Vijayraghavan
Master's Theses
Prostate cancer (PCa) is estimated to be the second leading cause of cancer-related deaths among men in the United States in 2019. While most prostate tumors rely on androgens for growth signaling, there are subsets of tumors that become androgen-resistant, therefore resisting conventional androgen-depravation therapy. Consequently, research has focused on targeting different hormone receptors for novel therapeutics. One such receptor is Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 (DAX-1). DAX-1 is known to interact with other hormone receptors, such as androgen receptor (AR) and estrogen receptors (ERs) to suppress the proliferative effects …
Play Behavior And The Development Of Boldness And Caution In Juvenile Belding’S Ground Squirrels (Urocitellus Beldingi), Madelene Shehan
Play Behavior And The Development Of Boldness And Caution In Juvenile Belding’S Ground Squirrels (Urocitellus Beldingi), Madelene Shehan
Master's Theses
The ubiquity of play among juvenile mammals suggests it provides adaptive benefits, potentially through influences on the development of temperament in young animals. Juvenile Belding’s ground squirrels (Urocitellus beldingi) must balance competing demands for boldness and caution imposed by the fundamental trade-off between their short active season and their vulnerability to predation. In this study, I evaluated whether play helps to facilitate the development of an appropriate balance between boldness and caution in juvenile U. beldingi.I observed the play behavior of juvenile U. beldingiand conducted flight-initiation distance tests to measure boldness-caution at the beginning and toward …
Differences In Thermal Niche Between Coastal And Inland Populations Of The Yellow Monkeyflower (Mimulus Guttatus), Alec J. Chiono, John R. Paul
Differences In Thermal Niche Between Coastal And Inland Populations Of The Yellow Monkeyflower (Mimulus Guttatus), Alec J. Chiono, John R. Paul
Creative Activity and Research Day - CARD
Climate change will have multiple important impacts on coastal plant communities, yet how coastal plants will respond to temperature increases is understudied. Coastal areas experience small fluctuations in temperature daily and annually, similar to lowland tropical environments where research has shown that some tropical organisms are extremely threatened by increases in temperature because their thermal environmental has, historically, been very stable. Using multiple approaches, we plan to study if coastal and inland populations of the plant Mimulus guttatus differ in the evolution of their thermal niches. Are coastal populations more sensitive to changes in temperature, have coastal populations been limited …
Evaluating Centric Diatom Diversity In San Francisco Bay With Scanning Electron Microscopy, Ria Angelica Laxa, Jina Ham
Evaluating Centric Diatom Diversity In San Francisco Bay With Scanning Electron Microscopy, Ria Angelica Laxa, Jina Ham
Creative Activity and Research Day - CARD
Since September 2015, research has been conducted at the University of San Francisco (USF) to study planktonic diatoms in San Francisco Bay. Planktonic diatoms are one of the greatest contributors to the biodiversity in estuary systems. Due to their primary position in the food chain, changes in planktonic diatom communities will affect marine organisms at higher trophic levels. Therefore, the abundance and diversity of diatom species allows for the measurement of the health of the marine ecosystem. A previous study by Keith (2018), focused on documenting changes in species diversity over time, observing seasonal patterns in species richness as well …
Size Resistance To Infection With The Schistosome Parasite In The Vector Snail, Nicholas Tellechea, Mariam Banoub, Petros Minasi
Size Resistance To Infection With The Schistosome Parasite In The Vector Snail, Nicholas Tellechea, Mariam Banoub, Petros Minasi
Creative Activity and Research Day - CARD
Schistosomiasis is a parasitic disease that infects 200 million individuals, in mainly undeveloped countries, killing thousands. Schistosoma mansoni is one causative parasite, and it is transmitted by the freshwater snail Biomphalaria glabrata. B. glabrata snails of the BS-90 strain have shown neonatal susceptibility to the parasite, while adults are resistant, although the mechanism is unknown. Here we show that resistance to the parasite may be a function of snail size, since prevalence of infection is lower in larger snails, and since larval parasites (sporocysts) in larger snails have fewer germinal cells, are surrounded by a multilayered capsule of hemocytes, …
Mice Fed An Obesogenic Western Diet, Administered Antibiotics, And Subjected To A Sterile Surgical Procedure Develop Lethal Septicemia With Multidrug-Resistant Pathobionts, Sanjiv K. Hyoju, Alexander Zaborin, Robert Keskey, Anukriti Sharma, Wyatt Arnold, Fons Van Den Berg, Sangman Michael Kim, Neil Gottel, Cindy Bethel, Angella Charnot-Katsikas, Peng Jianxin, Carleen Adriaansens, Emily Papazian, Jack A. Gilbert, Olga Zaborina, John C. Alverdy
Mice Fed An Obesogenic Western Diet, Administered Antibiotics, And Subjected To A Sterile Surgical Procedure Develop Lethal Septicemia With Multidrug-Resistant Pathobionts, Sanjiv K. Hyoju, Alexander Zaborin, Robert Keskey, Anukriti Sharma, Wyatt Arnold, Fons Van Den Berg, Sangman Michael Kim, Neil Gottel, Cindy Bethel, Angella Charnot-Katsikas, Peng Jianxin, Carleen Adriaansens, Emily Papazian, Jack A. Gilbert, Olga Zaborina, John C. Alverdy
Biology Faculty Publications
Despite antibiotics and sterile technique, postoperative infections remain a real and present danger to patients. Recent estimates suggest that 50% of the pathogens associated with postoperative infections have become resistant to the standard antibiotics used for prophylaxis. Risk factors identified in such cases include obesity and antibiotic exposure. To study the combined effect of obesity and antibiotic exposure on postoperative infection, mice were allowed to gain weight on an obesogenic Western-type diet (WD), administered antibiotics and then subjected to an otherwise recoverable sterile surgical injury (30% hepatectomy). The feeding of a WD alone resulted in a major imbalance of the …