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Full-Text Articles in Life Sciences
Genetics Of Intercellular Signalling In C. Elegans, Judith Austin, Eleanor M. Maine, Judith Kimble
Genetics Of Intercellular Signalling In C. Elegans, Judith Austin, Eleanor M. Maine, Judith Kimble
Biology - All Scholarship
Cell-cell interactions play a significant role in controlling cell fate during development of the nematode Caenorhabditis elegans. It has been found that two genes, glp-1 and lin-12, are required for many of these decisions. glp-1 is required for induction of mitotic proliferation in the germline by the somatic distal tip cell and for induction of the anterior pharynx early in embryogenesis. lin-12 is required for the interactions between cells of equivalent developmental potential, which allow them to take on different fates. Comparison of these two genes on a molecular level indicates that they are similar in sequence and organization, suggesting …
The Drosophila Female-Specific Sex-Determination Gene, Sex-Lethal, Has Stage-, Tissue-, And Sex-Specific Rnas Suggesting Multiple Modes Of Regulation, Helen K. Salz, Eleanor M. Maine, Linda N. Keyes, Mark E. Samuels, Thomas W. Cline, Paul Schedl
The Drosophila Female-Specific Sex-Determination Gene, Sex-Lethal, Has Stage-, Tissue-, And Sex-Specific Rnas Suggesting Multiple Modes Of Regulation, Helen K. Salz, Eleanor M. Maine, Linda N. Keyes, Mark E. Samuels, Thomas W. Cline, Paul Schedl
Biology - All Scholarship
For proper sexual development of females, the Sex-lethal (Sxl) gene must be activated early in development and remain on during the rest of the life cycle. Conversely, in males, Sxl must remain functionally off through development. Here, we show that the Sxl transcription unit spans a DNA segment of greater than 20 kb and encodes at least 10 distinct, but overlapping, RNA species. These RNAs range in size from 4.4 to 1.7 kb and exhibit sex, stage, and tissue specificity. Six RNAs, three female specific and three male specific, are first detected by midembryogenesis and persist through the adult stage: …