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Full-Text Articles in Life Sciences
Efficient Alignment Algorithms For Dna Sequencing Data, Nilesh Vinod Khiste
Efficient Alignment Algorithms For Dna Sequencing Data, Nilesh Vinod Khiste
Electronic Thesis and Dissertation Repository
The DNA Next Generation Sequencing (NGS) technologies produce data at a low cost, enabling their application to many ambitious fields such as cancer research, disease control, personalized medicine etc. However, even after a decade of research, the modern aligners and assemblers are far from providing efficient and error free genome alignments and assemblies respectively. This is due to the inherent nature of the genome alignment and assembly problem, which involves many complexities. Many algorithms to address this problem have been proposed over the years, but there still is a huge scope for improvement in this research space.
Many new genome …
Error Correction And De Novo Genome Assembly Of Dna Sequencing Data, Michael Z. Molnar
Error Correction And De Novo Genome Assembly Of Dna Sequencing Data, Michael Z. Molnar
Electronic Thesis and Dissertation Repository
The ability to obtain the genetic code of any species has caused a revolution in biological sciences. Current technologies are capable of sequencing short pieces of DNA with very high quality. These short pieces of DNA determint the sequence of bases in the genome of any species. This information is key in understanding many of the aspects of how life functions.
The accuracy of sequencing is extremely important since the differences between individuals of the same species are caused by very few changes. All sequencing technologies make errors, and before the data can be used for downstream applications it is …