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Full-Text Articles in Life Sciences
Algorithms For Glycan Structure Identification With Tandem Mass Spectrometry, Weiping Sun
Algorithms For Glycan Structure Identification With Tandem Mass Spectrometry, Weiping Sun
Electronic Thesis and Dissertation Repository
Glycosylation is a frequently observed post-translational modification (PTM) of proteins. It has been estimated over half of eukaryotic proteins in nature are glycoproteins. Glycoprotein analysis plays a vital role in drug preparation. Thus, characterization of glycans that are linked to proteins has become necessary in glycoproteomics. Mass spectrometry has become an effective analytical technique for glycoproteomics analysis because of its high throughput and sensitivity. The large amount of spectral data collected in a mass spectrometry experiment makes manual interpretation impossible and requires effective computational approaches for automated analysis. Different algorithmic solutions have been proposed to address the challenges in glycoproteomics …
Measuring The Human Gut Microbiome: New Tools And Non Alcoholic Fatty Liver Disease, Ruth G. Wong
Measuring The Human Gut Microbiome: New Tools And Non Alcoholic Fatty Liver Disease, Ruth G. Wong
Electronic Thesis and Dissertation Repository
With the advent of next generation DNA and RNA sequencing, scientists can obtain a more comprehensive snapshot of the bacterial communities on the human body (known as the `human microbiome'), leading to information about the bacterial composition, what genes are present, and what proteins are produced. The scientific community is in a phase of developing the experiments and accompanying statistical techniques to investigate the mechanisms by which the human microbiome affects health and disease. In this thesis, I explore alternatives to the standard weighted and unweighted UniFrac distance metric that measure the difference between microbiome samples. These alternative weightings allow …