Open Access. Powered by Scholars. Published by Universities.®
Biochemistry, Biophysics, and Structural Biology
Arts & Sciences Electronic Theses and Dissertations
Computational methods, conformational ensembles, intrinsically disordered proteins, phase equilibrium
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Computational Methods For Analysis Of Data For Conformational And Phase Equilibria Of Disordered Proteins, Jared Michael M Lalmansingh
Computational Methods For Analysis Of Data For Conformational And Phase Equilibria Of Disordered Proteins, Jared Michael M Lalmansingh
Arts & Sciences Electronic Theses and Dissertations
Intrinsically disordered proteins and regions (IDPs / IDRs) are a class of proteins with diverse conformational heterogeneity that do not fold into a tertiary structure due to the lack of a native structural state. Consequently, disordered proteins are remarkably flexible and exhibit multivalent properties that enable them to adopt myriad functional roles within the cell such as: signaling transduction, transcription, enzymatic catalysis, translation, and many more. Due to their multivalency, some IDPs undergo monomeric and heterotypic interactions which can drive phase separation. Such IDPs can form membraneless organelles with specific regulatory roles within the cell which include, but are not …