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- (RD19a) (1)
- A process termed mechanotransduction. Through cell-ECM focal adhesions (1)
- Aid in the advancement of both tissue engineering and cancer treatment research. (1)
- And polyacrylamide gels containing fluorescent beads. The mobility of integrin on the different substrates was assessed using fluorescent recovery after photo-bleaching (FRAP) and analyzed along with cell traction force measurements. These studies serve to further the understanding of our knowledge of integrin and its role in mechanotransduction and migration. It will (1)
- AngiognesisThe formation of new vasculature is an essential process (1)
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- Arsenic (1)
- Arsenic disruption (1)
- But can also be utilized by cancerous cells. Angiogenesis requires the directed migration of the endothelial cells lining the nascent blood vessels. This process is largely mediated by integrin (1)
- Candida albicans (1)
- Cystenine protease-encoding gene (1)
- Fast pyrolysis (1)
- Focal adhesion (1)
- Formic acid salts (1)
- Immunofluorescence microscopy (1)
- Integrin (1)
- Integrin mediates the signaling both into and out of the cell (1)
- Mast cell degranulation (1)
- Mechanism resistance (1)
- Mechanotransduction (1)
- Muconic acid (1)
- Myzus persicae (1)
- Pathogenic fungi (1)
- Polydimethylsiloxane (PDMS) micro pillars (1)
- Promoting growth of focal adhesions and subsequent cell spreading and migration. In order to study focal adhesion dynamics related to force (1)
- Reverse genetic analysis (1)
- Syk kinase (1)
- Therefore (1)
- Thermal deoxygenation (1)
- Vertebrate immunity (1)
- We observed cells on three different substrates: polyacrylamide gels (1)
Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
Fast Pyrolysis Of Muconic Acid And Formic Acid Salts, Laura Duran
Fast Pyrolysis Of Muconic Acid And Formic Acid Salts, Laura Duran
Honors College
Lignocellulosic biomass is emerging as a sustainable resource for the production of alternative liquid fuels. As the need to lessen dependence on petroleum sources grows, lignocellulosic feedstocks are being investigated as a renewable, abundant source of energy. Chemical pulping processes include a high-lignin by-product, black liquor, which is already used for fuel in industry. Black liquor is burned to generate steam and electricity and to recover pulping chemicals. Currently, the thermochemical conversion of black liquor to liquid fuel is being researched at The University of Maine. In this black liquor research, an intermediate lignin-derived acid, muconic acid, and formic acid …
Reverse Genetic Analysis Of A Cysteine Protease-Encoding Gene (Rd19a) Of Arabidopsis Thaliana In Relation To The Mechanism Of Resistance To The Piercing/Sucking Insect Myzus Persicae, Siobhan A. Cusack
Honors College
A recent study in Solanum bulbocastanum (a wild relative of the cultivated potato) aiming to identify potential genes involved in aphid and pathogen resistance mechanisms found that a homolog of the Arabidopsis thaliana cysteine protease gene RD19a is upregulated during aphid infestation. RD19a is upregulated in response to abiotic stresses such as drought and high salinity, and rd19a mutants show increased susceptibility to bacterial infection. In this study, Arabidopsis rd19a mutants and wild-type plants were subjected to aphid feeding to observe and compare the molecular, physiological and phenotypic responses. The aim was to further establish the proof of concept regarding …
Investigation Of The Mechanism Underlying Arsenic Disruption Of Mast Cell Degranulation, Alejandro Velez
Investigation Of The Mechanism Underlying Arsenic Disruption Of Mast Cell Degranulation, Alejandro Velez
Honors College
Exposure to arsenic (As) is a global health concern, according to the World Health Organization and Agency for Toxic Substances and Disease Registry. Prolonged exposure to this naturally occurring chemical has been linked to hyperkeratosis, type II diabetes, developmental abnormalities, and cancer. Some of the adverse health effects of As may be linked to its ability to alter cellular signal transduction. Recently, published work from the Gosse laboratory has shown that inorganic arsenite inhibits the signaling cascade leading to mast cell degranulation, a vital immune function, through an as-yet unknown mechanism.
Further work in the Gosse lab has suggested that …
Evolutionary And Molecular Analysis Of Conserved Vertebrate Immunity To Fungi, Erin Carter
Evolutionary And Molecular Analysis Of Conserved Vertebrate Immunity To Fungi, Erin Carter
Honors College
The innate immune system is highly conserved amongst all multicellular organisms. Yet a constant battle exists between host cells and pathogens due to the rapid evolution of immune system components. Functional genomics and in silico methods can be employed to elucidate the evolutionary patterns of vertebrate immunity to pathogenic fungi such as Candida albicans, an opportunistic fungal pathogen that can cause lethal candidiasis in the immunocompromised. Mammals such as humans and mice possess conserved C-type lectin receptors that recognize the C. albicans cell wall. However, these receptors have not been identified in fish. Here I describe how we identified potential …
A Novel Mechanism For Mechanosensing By Endothelial Cells, Jennifer Macdowell
A Novel Mechanism For Mechanosensing By Endothelial Cells, Jennifer Macdowell
Honors College
The formation of new vasculature is an essential process, but can also be utilized by cancerous cells. Angiogenesis requires the directed migration of the endothelial cells lining the nascent blood vessels. This process is largely mediated by integrin, which plays a key role in the interplay between sensing a force in the extracellular matrix (ECM) and transducing this signal, a process termed mechanotransduction. Through cell-ECM focal adhesions, integrin mediates the signaling both into and out of the cell, promoting growth of focal adhesions and subsequent cell spreading and migration. In order to study focal adhesion dynamics related to force, we …