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Fish Skeletal Muscle:Adenoisine Triphosphate And Adenine Nucleotide Metabolites In Relation To The Texture And Quality Of Fish, Carmel Wills
Fish Skeletal Muscle:Adenoisine Triphosphate And Adenine Nucleotide Metabolites In Relation To The Texture And Quality Of Fish, Carmel Wills
Doctoral
The changes which occurred in the concentrations of ATP, ADP, AMP, inosine monophosphate, inosine and hypoxanthine in skeletal muscle of rainbow trout, salmon and goldfish during the onset and resolution of rigor mortis were investigated. The effects of ante mortem handling and methods of slaughter on the concentrations of these nucleotides in muscle immediately after death and during storage of fish at 3° and at -30° were examined. Very careful handling of fish and killing by a method which did not cause contraction of muscle were essential if concentrations of ATP were to be at levels indicative of resting muscle …
Hyperinsulinism Caused By Paternal-Specific Inheritance Of A Recessive Mutation In The Sulfonylurea-Receptor Gene, Benjamin Glaser, Fergus Ryan, Marc Donath, Heddy Landau, Charles Stanley, Lester Baker, David Barton, Paul Thornton
Hyperinsulinism Caused By Paternal-Specific Inheritance Of A Recessive Mutation In The Sulfonylurea-Receptor Gene, Benjamin Glaser, Fergus Ryan, Marc Donath, Heddy Landau, Charles Stanley, Lester Baker, David Barton, Paul Thornton
Articles
Neonatal hyperinsulinism (HI) is a genetic disorder of pancreatic b-cells characterized by failure to suppress insulin secretion in the presence of hypoglycemia, resulting in brain damage or death if not adequately treated. Germline mutations in four genes have been associated with HI. Some patients have focal regions of b-cell proliferation (focal HI). Seventy HI probands in whom at least one S U R - 1 mutation was identified were studied. Clinical data from patients with two S U R - 1 mutant alleles were compared with those from patients with single paternally inherited mutations. Thirtyseven probands were homozygous or compound …