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Molecular Study Of The B19 (Human) Pathogenic Parvovirus, Jamshed Ayub
Molecular Study Of The B19 (Human) Pathogenic Parvovirus, Jamshed Ayub
Theses and Dissertations in Biomedical Sciences
The B19 (human) parvovirus is a small single stranded DNA virus of 5.4 kilobases. B19 is specific for erythroid progenitor cells and has been propagated in vitro only with human erythroid bone marrow. Replication of viral DNA and the viral protein products of B19 appear similar to those of other animal parvoviruses. However, B19 differs from other parvoviruses in some important aspects, which include the initiation of all transcripts at a strong left side promoter (p6) and the absence of a functional internal promoter. B19 has an unusual transcription map which is described in this study.
The transcription map of …