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Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
Microbial And Metabolomic Biomarkers Of Feed Efficiency In Angus Cattle, Brooke Ashley Clemmons
Microbial And Metabolomic Biomarkers Of Feed Efficiency In Angus Cattle, Brooke Ashley Clemmons
Doctoral Dissertations
In Tennessee and the United States, cattle account for a significant proportion of the livestock agricultural sector. In the beef cattle industry, 40-70% of the total cost of production comes from feed costs, resulting in billions of dollars going towards feeding cattle. Thus, identifying methods for improving feed efficiency is imperative for reduced feed input costs and more effective use of environmental and economic resources. The rumen microbiome contributes a vast amount of nutrients for the host ruminant, including approximately 70% of energy precursors as well as vitamins, proteins, and other nutrients. These microbes produce metabolites that are then available …
Interacting Effects Of Climate And Biotic Factors On Mesocarnivore Distribution And Snowshoe Hare Demography Along The Boreal-Temperate Ecotone, Alexej P. Siren
Interacting Effects Of Climate And Biotic Factors On Mesocarnivore Distribution And Snowshoe Hare Demography Along The Boreal-Temperate Ecotone, Alexej P. Siren
Doctoral Dissertations
The motivation of my dissertation research was to understand the influence of climate and biotic factors on range limits with a focus on winter-adapted species, including the Canada lynx (Lynx canadensis), American marten (Martes americana), and snowshoe hare (Lepus americanus). I investigated range dynamics along the boreal-temperate ecotone of the northeastern US. Through an integrative literature review, I developed a theoretical framework building from existing thinking on range limits and ecological theory. I used this theory for my second chapter to evaluate direct and indirect causes of carnivore range limits in the northeastern US, …
Physiology Of A Basal Vertebrate, The Sea Lamprey (Petromyzon Marinus): Osmoregulation And Corticosteroid Action, Ciaran A. S. Shaughnessy
Physiology Of A Basal Vertebrate, The Sea Lamprey (Petromyzon Marinus): Osmoregulation And Corticosteroid Action, Ciaran A. S. Shaughnessy
Doctoral Dissertations
Lamprey represent the most basal living example of a vertebrate animal which regulates its internal fluid and ion homeostasis. This phylogenetic position among vertebrates makes lamprey an important model organism for understanding the basal state, and thus the evolution, of physiological systems such as the mechanisms of osmo- and ionoregulation and the endocrine factors controlling them. Sea lamprey (Petromyzon marinus) are an anadromous fish, migrating from freshwater (FW) to seawater (SW) as juveniles, then returning back upstream as mature adults to spawn. Surviving this transition from a solute-poor FW environment to a solute-concentrated SW environment requires many changes …
Engineered Nanoparticles For Site-Specific Bioorthogonal Catalysis: Imaging And Therapy, Riddha Das
Engineered Nanoparticles For Site-Specific Bioorthogonal Catalysis: Imaging And Therapy, Riddha Das
Doctoral Dissertations
Bioorthogonal catalysis offers a strategy for chemical transformations complementary to bioprocesses and has proven to be a powerful tool in biochemistry and medical sciences. Transition metal catalysts (TMCs) have emerged as a powerful tool to execute selective chemical transformations, however, lack of biocompatibility and stability limits their use in biological applications. Incorporation of TMCs into nanoparticle monolayers provides a versatile strategy for the generation of bioorthogonal nanocatalysts known as “nanozymes”. We have fabricated a family of nanozymes using gold nanoparticles (AuNPs) as scaffolds featuring diverse chemical functional groups for controlled localization of nanozymes in biological environments, providing unique strategies for …
Tpr-Containing Proteins Control Protein Organization And Homeostasis For The Endoplasmic Reticulum, Jill Bradley-Graham
Tpr-Containing Proteins Control Protein Organization And Homeostasis For The Endoplasmic Reticulum, Jill Bradley-Graham
Doctoral Dissertations
The endoplasmic reticulum (ER) is a complex, multifunctional organelle comprised of a continuous membrane and lumen that is organized into several functional regions. It plays various roles including protein translocation, folding, quality control, secretion, calcium signaling, and lipid biogenesis. Cellular protein homeostasis is maintained by a complicated chaperone network, and the largest functional family within this network consists of proteins containing tetratricopeptide repeats (TPRs). TPRs are well-studied structural motifs that mediate intermolecular protein-protein interactions, supporting interactions with a wide range of ligands or substrates. Nine TPR-containing proteins have been shown to localize to the ER and control protein organization and …