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Roles For Estrogen And Progesterone In Breast Cancer Prevention, D. Joseph Jerry
Roles For Estrogen And Progesterone In Breast Cancer Prevention, D. Joseph Jerry
D. Joseph Jerry
Prevention has long been the holy grail of breast cancer research. The significant reduction in breast cancer risk afforded by a full-term pregnancy early in life suggests the great potential of preventive strategies. In contrast to the risks associated with prolonged exposures, exogenous estrogen and progesterone for short durations can mimic the protective effects of pregnancy in carcinogen-induced mammary tumor models. Rajkumar and coworkers have now demonstrated that these hormones protect mice from mammary tumors initiated by a spectrum of oncogenic alterations that are common in breast cancers. Although differences between rodent models and humans remain, the results reveal that …
Genetic Mapping In Mice Identifies Dmbt1 As A Candidate Modifier Of Breast Cancer Risk, A. C. Blackburn, L. Z. Hills, A. L. Roberts, J. Wang, D. Aud, J Jung, T. Nikolcheva, J. Allard, G. Peltz, C. N. Otis, Q. J. Cao, R. Ricketts, S.P. Mollenhauer, S. P. Naber, D. Malamud, A. Poustka, D. Joseph Jerry
Genetic Mapping In Mice Identifies Dmbt1 As A Candidate Modifier Of Breast Cancer Risk, A. C. Blackburn, L. Z. Hills, A. L. Roberts, J. Wang, D. Aud, J Jung, T. Nikolcheva, J. Allard, G. Peltz, C. N. Otis, Q. J. Cao, R. Ricketts, S.P. Mollenhauer, S. P. Naber, D. Malamud, A. Poustka, D. Joseph Jerry
D. Joseph Jerry
Low-penetrance breast cancer susceptibility alleles seem to play a significant role in breast cancer risk but are difficult to identify in human cohorts. A genetic screen of 176 N2 backcross progeny of two Trp53+/− strains, BALB/c and C57BL/6, which differ in their susceptibility to mammary tumors, identified a modifier of mammary tumor susceptibility in an ∼25-Mb interval on mouse chromosome 7 (designated SuprMam1). Relative to heterozygotes, homozygosity for BALB/c alleles of SuprMam1 significantly decreased mammary tumor latency from 70.7 to 61.1 weeks and increased risk twofold (P = 0.002). Dmbt1 (deleted in malignant brain tumors 1) was identified as a …