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Articles 1 - 8 of 8
Full-Text Articles in Life Sciences
Small-Animal Models Of Zika Virus, Justin G. Julander, Venkatraman Siddharthan
Small-Animal Models Of Zika Virus, Justin G. Julander, Venkatraman Siddharthan
Animal, Dairy, and Veterinary Science Faculty Publications
Zika virus (ZIKV) infection can result in serious consequences, including severe congenital manifestations, persistent infection in the testes and neurologic sequelae. After a pandemic emergence, the virus has spread to much of the new world and has been introduced to many countries outside of endemic areas as infected travelers return to their home countries. Rodent models have been important in gaining a better understanding of the wide range of disease etiologies associated with ZIKV infection and for the initial phase of developing countermeasures to prevent or treat viral infections. We discuss herein the advantages and disadvantages of small animal models …
Data On The Effect Of In Utero Exposure To Polycyclic Aromatic Hydrocarbons On Genome-Wide Patterns Of Dna Methylation In Lung Tissues, Trevor J. Fish, Abby D. Benninghoff
Data On The Effect Of In Utero Exposure To Polycyclic Aromatic Hydrocarbons On Genome-Wide Patterns Of Dna Methylation In Lung Tissues, Trevor J. Fish, Abby D. Benninghoff
Animal, Dairy, and Veterinary Science Faculty Publications
Data in this article depict patterns of methylation in lung tissues obtained from the offspring of B6129SF1/J dams and 129S1/SvImJ sires exposed in utero to benzo[a]pyrene (BaP) or dibenzo[def,p]chrysene (DBC) as compared to non-exposed offspring. Genome-wide methylation of lung tumors in adult offspring was determined using methylated DNA immunoprecipitation (MeDIP) with the NimbleGen mouse DNA methylation CpG island array. This data article refers to the research article “DNA methylation in lung tissues of mouse offspring exposed in utero to polycyclic aromatic hydrocarbons,” in which comprehensive data interpretation and analysis are provided.
Serum Biochemistry Panels In African Buffalo: Defining Reference Intervals And Assessing Variability Across Season, Age And Sex, Johanna Rigas, Claire E. Couch, Morgan A. Movius, Anna E. Jolles, M Elena Gorman, Brianna R. Beechler
Serum Biochemistry Panels In African Buffalo: Defining Reference Intervals And Assessing Variability Across Season, Age And Sex, Johanna Rigas, Claire E. Couch, Morgan A. Movius, Anna E. Jolles, M Elena Gorman, Brianna R. Beechler
Animal, Dairy, and Veterinary Science Faculty Publications
Serum biochemical parameters can be utilized to evaluate the physiological status of an animal, and relate it to the animal’s health. In order to accurately interpret individual animal biochemical results, species-specific reference intervals (RI) must be established. Reference intervals for biochemical parameters differ between species, and physiological differences including reproductive status, nutritional resource availability, disease status, and age affect parameters within the same species. The objectives of this study were to (1) establish RI for biochemical parameters in managed African buffalo (Syncerus caffer), (2) assess the effects of age, sex, pregnancy, and season on serum biochemistry values, and (3) compare …
Extension Education Symposium: Getting The Most Out Of Your Extension Appointment And Still Having A Life, W. Powers, Noelle E. Cockett, Gregory P. Lardy
Extension Education Symposium: Getting The Most Out Of Your Extension Appointment And Still Having A Life, W. Powers, Noelle E. Cockett, Gregory P. Lardy
Animal, Dairy, and Veterinary Science Faculty Publications
Managing the demands of an academic appointment in extension can be a challenging task. Demands from constituent groups, expectations of supervisors, and rigors of promotion and tenure processes can create pressures that young faculty did not expect. Throw in spousal and family duties and you have created a situation that many will find hard to navigate. However, there are ways to cope and, even better news, there are ways to excel in meeting the demands of an academic appointment and enjoying life. Because many new extension faculty members do not have prior experience in extension, best practices in documenting programs …
Consumer Sensory Evaluation And Chemical Composition Of Beef Gluteus Medius And Triceps Brachii Steaks From Cattle Finished On Forage Or Concentrate Diets, A. Chail, Jerrad F. Legako, L. R. Pitcher, Robert E. Ward, Silvana Martini, Jennifer W. Macadam
Consumer Sensory Evaluation And Chemical Composition Of Beef Gluteus Medius And Triceps Brachii Steaks From Cattle Finished On Forage Or Concentrate Diets, A. Chail, Jerrad F. Legako, L. R. Pitcher, Robert E. Ward, Silvana Martini, Jennifer W. Macadam
Animal, Dairy, and Veterinary Science Faculty Publications
The objective of this study was to assess the impact of cattle finishing diet and muscle type on meat quality. Consumer sensory response, proximate composition, Warner–Bratzler shear force (WBSF), fatty acid composition, and volatile compounds were assessed from the gluteus medius (GM) and triceps brachii (TB) muscles of cattle (n = 6 per diet) which were grain-finished (USUGrain) on conventional feedlot or 2 forage diets, a perennial legume, birdsfoot trefoil-fin-ished (USUBFT; Lotus corniculatus), and grass-finished (USUGrass; Bromus riparius). Diet had an interacting effect with muscle for all sensory attributes (P ≤ 0.002), except aroma and flavor (P ≥ 0.078). In …
Estimation Of The Trichomonad Concentration In Beef Bull Preputial Samples And Resultant Population Effect Of Pooling On Detection Of Tritrichomonas Foetus Using Qpcr, David J. Wilson, Thomas J. Baldwin, Amanda Wilhelm, Chelsea H. Whitehouse, Jennifer L. Bunnell, Kerry A. Rood, Arnaud Van Wettere
Estimation Of The Trichomonad Concentration In Beef Bull Preputial Samples And Resultant Population Effect Of Pooling On Detection Of Tritrichomonas Foetus Using Qpcr, David J. Wilson, Thomas J. Baldwin, Amanda Wilhelm, Chelsea H. Whitehouse, Jennifer L. Bunnell, Kerry A. Rood, Arnaud Van Wettere
Animal, Dairy, and Veterinary Science Faculty Publications
The primary objective was assessment of effect of sample pooling on Tritrichomonas foetus detection using qPCR in beef bulls within 5 logs of trichomonad concentration in spiked preputial samples. The secondary objective was to use qPCR Ct values to estimate the percentage of beef bulls in the field population within each log of trichomonad concentration. Solutions containing none, 1,10,100,1000 and 10,000 trichomonads (T)/ml were made and tested by qPCR. Test sensitivities for single positive samples were: 1 T/ml, 20/40 (50%); 10 T/ml, 40/40 (100%); 100 T/ml, 40/40 (100%); 1000 T/ml, 40/40 (100%); 10,000 T/ml, 40/40 (100%). For 5-sample pools (1 …
The Influence Of Oblique Angle Forced Exercise In Surgically Destabilized Stifle Joints Is Synergistic With Bone, But Antagonistic With Cartilage In An Ovine Model Of Osteoarthritis, Rachel J. Hill, Holly M. Mason, Gavin Yeip, Samer S. Merchant, Aaron L. Olsen, Rusty D. Stott, Arnaud J. Van Wettere, Eadric Bressel, Jeffrey B. Mason
The Influence Of Oblique Angle Forced Exercise In Surgically Destabilized Stifle Joints Is Synergistic With Bone, But Antagonistic With Cartilage In An Ovine Model Of Osteoarthritis, Rachel J. Hill, Holly M. Mason, Gavin Yeip, Samer S. Merchant, Aaron L. Olsen, Rusty D. Stott, Arnaud J. Van Wettere, Eadric Bressel, Jeffrey B. Mason
Animal, Dairy, and Veterinary Science Faculty Publications
Large animal models of osteoarthritis are a necessary testing ground for FDA approval of human medicine applications. Sheep models have advantages over other available large animals, but development and progression of osteoarthritis in sheep is exceedingly slow, which handicaps progress in development of potential treatments. We combined oblique angle forced exercise to increase stress on the stifle, with surgical destabilization to hasten the development of osteoarthritis in ewes. Methods for early detection of clinical signs included radiography, urine, and serum biomarker assays and gait analysis and ex vivo we used microcomputed tomography and macroscopic joint analysis. Our model was able …
Modeling Severe Fever With Thrombocytopenia Syndrome Virus Infection In Golden Syrian Hamsters: Importance Of Stat2 In Preventing Disease And Effective Treatment With Favipiravir, Brian B. Gowen, Jonna B. Westover, Jinxin Miao, Arnaud J. Van Wettere, Johanna D. Rigas, Brady T. Hickerson, Kie-Hoon Jung, Rong Li, Bettina L. Conrad, Skot Nielson, Yousuke Furuta, Zhongde Wang
Modeling Severe Fever With Thrombocytopenia Syndrome Virus Infection In Golden Syrian Hamsters: Importance Of Stat2 In Preventing Disease And Effective Treatment With Favipiravir, Brian B. Gowen, Jonna B. Westover, Jinxin Miao, Arnaud J. Van Wettere, Johanna D. Rigas, Brady T. Hickerson, Kie-Hoon Jung, Rong Li, Bettina L. Conrad, Skot Nielson, Yousuke Furuta, Zhongde Wang
Animal, Dairy, and Veterinary Science Faculty Publications
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease endemic in parts of Asia. The etiologic agent, SFTS virus (SFTSV; family Bunyaviridae, genus Phlebovirus) has caused significant morbidity and mortality in China, South Korea, and Japan, with key features of disease being intense fever, thrombocytopenia, and leukopenia. Case fatality rates are estimated to be in the 30% range, and no antivirals or vaccines are approved for use for treatment and prevention of SFTS. There is evidence that in human cells, SFTSV sequesters STAT proteins in replication complexes, thereby inhibiting type I interferon signaling. Here, we demonstrate …