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Full-Text Articles in Life Sciences
Coumarins And Pyranocoumarins, Potential Novel Pharmacophores For Inhibition Ofmeasles Virus Replication, Dale L. Barnard, Z. Q. Xu, V. D. Stowell, H. Yuan, Donald F. Smee, R. Samy, R. W. Sidwell, M. K. Nielsen, L. Sun, H. Cao, A. Li, C. Quint, J. Deignan, J. Crabb, M. T. Flavin
Coumarins And Pyranocoumarins, Potential Novel Pharmacophores For Inhibition Ofmeasles Virus Replication, Dale L. Barnard, Z. Q. Xu, V. D. Stowell, H. Yuan, Donald F. Smee, R. Samy, R. W. Sidwell, M. K. Nielsen, L. Sun, H. Cao, A. Li, C. Quint, J. Deignan, J. Crabb, M. T. Flavin
Animal, Dairy, and Veterinary Science Faculty Publications
A series of coumarin and pyranocoumarin analogues were evaluated in vitro for antiviral efficacy against measles virus (MV), strain Chicago. Of the 22 compounds tested for inhibition, six were found to have selectivity indices greater than 10. These were compounds 5-hydroxy-7-propionyloxy- 4-propylcoumarin (2a), 5,7-bis(tosyloxy)-4- propylcoumarin (7); 5-hydroxy-4-propyl-7-tosyloxy- coumarin (8); 6,6-dimethyl-9-propionyloxy-4- propyl-2H,6H-benzo[1,2-b:3,4-b′]dipyran-2-one (9); 6,6-dimethyl-9-pivaloyloxy-4-propyl-2H,6Hbenzo[ 1,2-b:3,4-b′]dipyran-2-one (10); and 7,8-cis- 10,11,12-trans-4-propyl-6,6,10,11-tetramethyl- 7,8,9-trihydroxy-2H,6H,12H-benzo[1,2-b:3,4-b′:5,6- b′′]tripyran-2-one (18). Three of the active drugs were propyl coumarin analogues (2a, 7 and 8), two were dipyranone or chromeno-coumarins (9 and 10), and one was a benzotripyranone with a coumarin nucleus (18). Some appeared to be rather specific and potent …
Viramidine, Dale L. Barnard
Viramidine, Dale L. Barnard
Animal, Dairy, and Veterinary Science Faculty Publications
No abstract provided.
Interferon-Alpha, Dale L. Barnard
Interferon-Alpha, Dale L. Barnard
Animal, Dairy, and Veterinary Science Faculty Publications
Amarillo Biosciences is developing low-dose oral interferon-alpha (IFNalpha; Veldona) as a potential treatment for primary Sjøgren's syndrome, oral mucositis in cancer patients, hepatitis B and C virus (HBV and HCV) infections, and bone marrow disorders. The company is also developing a topical formulation of IFNalpha for the potential treatment of genital warts. The product is registered in Ghana for the treatment of HBV infection. In October 2001, Amarillo licensed rights to its low-dose oral IFNalpha to Atrix Laboratories for the Orphan indications of oral papillomavirus and Behçet's disease.