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Full-Text Articles in Life Sciences
Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements For Nad+ Synthesis, Laura Palzer, Jessica J. Bader, Frances Angel, Megan Witzel, Sydney Blaser, Alexis Mcneil, Miles K. Wandersee, N. Adrian Leu, Christopher J. Lengner, Clara E. Cho, Kevin D. Welch, James B. Kirkland, Ralph G. Meyer, Mirella L. Meyer-Ficca
Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements For Nad+ Synthesis, Laura Palzer, Jessica J. Bader, Frances Angel, Megan Witzel, Sydney Blaser, Alexis Mcneil, Miles K. Wandersee, N. Adrian Leu, Christopher J. Lengner, Clara E. Cho, Kevin D. Welch, James B. Kirkland, Ralph G. Meyer, Mirella L. Meyer-Ficca
Animal, Dairy, and Veterinary Science Faculty Publications
NAD+ is essential for redox reactions in energy metabolism and necessary for DNA repair and epigenetic modification. Humans require sufficient amounts of dietary niacin (nicotinic acid, nicotinamide, and nicotinamide riboside) for adequate NAD+ synthesis. In contrast, mice easily generate sufficient NAD+ solely from tryptophan through the kynurenine pathway. We show that transgenic mice with inducible expression of human alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) become niacin dependent similar to humans when ACMSD expression is high. On niacin-free diets, these acquired niacin dependency (ANDY) mice developed reversible, mild-to-severe NAD+ deficiency, depending on the nutrient composition of the diet. NAD deficiency …
Germ Cell Depletion Influenced Neuromuscular, Sensory, Renal And Metabolic Function In Postreproductive Female Mice, Tracy L. Habermehl, Kate C. Parkinson, Jeffrey B. Mason
Germ Cell Depletion Influenced Neuromuscular, Sensory, Renal And Metabolic Function In Postreproductive Female Mice, Tracy L. Habermehl, Kate C. Parkinson, Jeffrey B. Mason
Animal, Dairy, and Veterinary Science Faculty Publications
Numerous observations suggest a relationship between reproduction and health. This relationship has been difficult to define, particularly in mammals. At menopause, germ cell-diminished ovaries are relatively senescent. In mice, replacement of these senescent ovaries with young, actively cycling ovaries significantly increased life and health span in recipients. While we were successful in extending life and health span in postreproductive females, these experiments were not designed to distinguish between the contributions of ovarian hormones from actively cycling germ cells and the somatic tissue components of the ovaries. In the current study, we used 4-vinylcyclohexene diepoxide to deplete ovarian germ cells in …
Simultaneous Metabolic Quantification To Improve Mechanistic Understanding Of Nutrient Function And Efficacy, Clara E. Cho
Simultaneous Metabolic Quantification To Improve Mechanistic Understanding Of Nutrient Function And Efficacy, Clara E. Cho
Funded Research Records
No abstract provided.