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Humanized Monoclonal Antibody Against West Nile Virus Envelope Protein Administered After Neuronal Infection Protects Against Lethal Encephalitis In Hamsters, John D. Morrey, V. Siddharthan, Aaron L. Olsen, G. Y. Roper, H. Wang, Thomas J. Baldwin, S. Koenig, S. Johnson, J. L. Nordstrom, M. S. Diamond
Humanized Monoclonal Antibody Against West Nile Virus Envelope Protein Administered After Neuronal Infection Protects Against Lethal Encephalitis In Hamsters, John D. Morrey, V. Siddharthan, Aaron L. Olsen, G. Y. Roper, H. Wang, Thomas J. Baldwin, S. Koenig, S. Johnson, J. L. Nordstrom, M. S. Diamond
Animal, Dairy, and Veterinary Science Faculty Publications
Humans infected with West Nile virus (WNV) may clinically present with symptoms that are suggestive of neurological infection. Nearly all treatments of WNV disease have been effective in animal models only if administered before or soon after viral challenge. Here, we evaluated whether a potent neutralizing anti-WNV humanized monoclonal antibody (MAb), hE16, could improve the course of disease in a hamster model when administered after the virus had infected neurons in the brain. Five days after viral injection, WNV was detected in the brains of hamsters by cytopathic assay, quantitative reverse-transcription polymerase chain reaction, and immunohistochemical staining of WNV envelope …