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Anti-Hepatitis B Virus Activity Of Ori-9020, A Novel Phosphorothioate Dinucleotide, In A Transgenic Mouse Model, R. P. Iyer, A. Roland, Y. Jin, S. Mounir, B. Korba, Justin G. Julander, John D. Morrey
Anti-Hepatitis B Virus Activity Of Ori-9020, A Novel Phosphorothioate Dinucleotide, In A Transgenic Mouse Model, R. P. Iyer, A. Roland, Y. Jin, S. Mounir, B. Korba, Justin G. Julander, John D. Morrey
John D. Morrey
ORI-9020, a novel dinucleotide, evaluated in transgenic mice expressing hepatitis B virus (HBV), significantly reduced liver HBV DNA (P <= 0.001). Levels of HBeAg and HBsAg in serum and of HBcAg in liver were not affected by treatment. A minimal effective dosage was determined to be between 1.6 and 0.5 mg/kg of body weight/day, which was similar to that observed for adefovir dipivoxil.